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Alterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders.
Hoheisel, Linnea; Kambeitz-Ilankovic, Lana; Wenzel, Julian; Haas, Shalaila S; Antonucci, Linda A; Ruef, Anne; Penzel, Nora; Schultze-Lutter, Frauke; Lichtenstein, Theresa; Rosen, Marlene; Dwyer, Dominic B; Salokangas, Raimo K R; Lencer, Rebekka; Brambilla, Paolo; Borgwardt, Stephan; Wood, Stephen J; Upthegrove, Rachel; Bertolino, Alessandro; Ruhrmann, Stephan; Meisenzahl, Eva; Koutsouleris, Nikolaos; Fink, Gereon R; Daun, Silvia; Kambeitz, Joseph.
Afiliación
  • Hoheisel L; Cognitive Neuroscience (INM-3), Institute of Neurosciences and Medicine, Forschungszentrum Jülich, Jülich, Germany; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
  • Kambeitz-Ilankovic L; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany; Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany.
  • Wenzel J; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
  • Haas SS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Antonucci LA; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
  • Ruef A; Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany.
  • Penzel N; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Schultze-Lutter F; Department of Psychiatry and Psychotherapy, University of Düsseldorf, Düsseldorf, Germany; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Department of Psychology and Mental Health, Faculty of Psychology, Airlangga University, Surabay
  • Lichtenstein T; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
  • Rosen M; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
  • Dwyer DB; Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia; Orygen, Parkville, Victoria, Australia.
  • Salokangas RKR; Department of Psychiatry, University of Turku, Turku, Finland.
  • Lencer R; Institute for Translational Psychiatry, University of Münster, Münster, Germany; Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany.
  • Brambilla P; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Department of Neurosciences and Mental Health, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Borgwardt S; Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany.
  • Wood SJ; Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia; Orygen, Parkville, Victoria, Australia; Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom.
  • Upthegrove R; Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom; Centre for Human Brain Health, University of Birmingham, Birmingham, United Kingdom; Birmingham Early Interventions Service, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom.
  • Bertolino A; Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
  • Ruhrmann S; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
  • Meisenzahl E; Department of Psychiatry and Psychotherapy, University of Düsseldorf, Düsseldorf, Germany.
  • Koutsouleris N; Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany.
  • Fink GR; Cognitive Neuroscience (INM-3), Institute of Neurosciences and Medicine, Forschungszentrum Jülich, Jülich, Germany; Department of Neurology, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
  • Daun S; Cognitive Neuroscience (INM-3), Institute of Neurosciences and Medicine, Forschungszentrum Jülich, Jülich, Germany; Institute of Zoology, University of Cologne, Cologne, Germany.
  • Kambeitz J; Cognitive Neuroscience (INM-3), Institute of Neurosciences and Medicine, Forschungszentrum Jülich, Jülich, Germany; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. Electronic address: Joseph.Kambeitz@uk-koeln.de.
Biol Psychiatry Cogn Neurosci Neuroimaging ; 9(8): 765-776, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38461964
ABSTRACT

BACKGROUND:

Patients with psychosis and patients with depression exhibit widespread neurobiological abnormalities. The analysis of dynamic functional connectivity (dFC) allows for the detection of changes in complex brain activity patterns, providing insights into common and unique processes underlying these disorders.

METHODS:

We report the analysis of dFC in a large sample including 127 patients at clinical high risk for psychosis, 142 patients with recent-onset psychosis, 134 patients with recent-onset depression, and 256 healthy control participants. A sliding window-based technique was used to calculate the time-dependent FC in resting-state magnetic resonance imaging data, followed by clustering to reveal recurrent FC states in each diagnostic group.

RESULTS:

We identified 5 unique FC states, which could be identified in all groups with high consistency (mean r = 0.889 [SD = 0.116]). Analysis of dynamic parameters of these states showed a characteristic increase in the lifetime and frequency of a weakly connected FC state in patients with recent-onset depression (p < .0005) compared with the other groups and a common increase in the lifetime of an FC state characterized by high sensorimotor and cingulo-opercular connectivities in all patient groups compared with the healthy control group (p < .0002). Canonical correlation analysis revealed a mode that exhibited significant correlations between dFC parameters and clinical variables (r = 0.617, p < .0029), which was associated with positive psychosis symptom severity and several dFC parameters.

CONCLUSIONS:

Our findings indicate diagnosis-specific alterations of dFC and underline the potential of dynamic analysis to characterize disorders such as depression and psychosis and clinical risk states.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Imagen por Resonancia Magnética Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Biol Psychiatry Cogn Neurosci Neuroimaging Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Imagen por Resonancia Magnética Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Biol Psychiatry Cogn Neurosci Neuroimaging Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos