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Exposure to polymetallic contaminated sites induced toxicological effects on chicken lungs: A multi-level analysis.
Elkribi-Boukhris, Sameh; Boughattas, Iteb; Sappin-Didier, Valérie; Helaoui, Sondes; Coriou, Cécile; Bussiere, Sylvie; Mokni, Moncef; Banni, Mohamed.
Afiliación
  • Elkribi-Boukhris S; Department of Biological Sciences, University of Tunis El Manar, Tunis, Tunisia; Laboratory of Biochemistry and Environmental Toxicology, Higher Institute of Agronomy Chott-Mariem, Tunisia.
  • Boughattas I; Laboratory of Biochemistry and Environmental Toxicology, Higher Institute of Agronomy Chott-Mariem, Tunisia; Regional Field Crops Research Center of Beja, IRESA, Tunisia. Electronic address: iteb.boughattas@yahoo.fr.
  • Sappin-Didier V; UMR ISPA, Bordeaux Sciences Agro, INRA, 33140, Villenave D'Ornon, France.
  • Helaoui S; Laboratory of Biochemistry and Environmental Toxicology, Higher Institute of Agronomy Chott-Mariem, Tunisia.
  • Coriou C; UMR ISPA, Bordeaux Sciences Agro, INRA, 33140, Villenave D'Ornon, France.
  • Bussiere S; UMR ISPA, Bordeaux Sciences Agro, INRA, 33140, Villenave D'Ornon, France.
  • Mokni M; Department of Pathology, CHU Farhat Hached, Sousse, Tunisia.
  • Banni M; Laboratory of Biochemistry and Environmental Toxicology, Higher Institute of Agronomy Chott-Mariem, Tunisia; Higher Institute of Biotechnology, Monastir University, Tunisia.
Chemosphere ; 354: 141574, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38460845
ABSTRACT
Heavy metal pollution is an important environmental issue causing several hazards to organisms. In the present study, we investigated the uptake and accumulation of heavy metals (Pb, Cd, Cu, and Zn) in chicken lungs after six months of breeding on polymetallic-contaminated area in Jebel Ressas village. Genotoxicity in term of micronuclei frequency as well as oxidative stress in term of enzymatic activities of Catalase (CAT), Glutathion-S-Transferase (GST) and malondialdehydes accumulation (MDA) were performed. In addition, gene expression levels involved in oxidative stress genes (cat, sod and gst), metal homeostasis (mt1 and mt4) and DNA metabolism (p53, bcl2, caspase 3 and DNA ligase) were detected. Exposed chicken lungs revealed an important heavy metal accumulation of Cd and Zn co-occurring with oxidative status modulation. Transcriptomic results unveiled an upregulation of oxidative stress and homeostasis genes. On the other hand, genes involved in DNA metabolism indicated cellular functioning towards cells death and apoptosis modulation. Moreover, the histopathological examination revealed lung lesions in the chickens exposed to heavy metal contamination. Our study highlights the hazardous effects of heavy metal pollution on chicken respiratory system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Metales Pesados Límite: Animals Idioma: En Revista: Chemosphere Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Metales Pesados Límite: Animals Idioma: En Revista: Chemosphere Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Reino Unido