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Using transcranial alternating current stimulation to enhance working memory skills in youths with 22q11.2 deletion syndrome: A randomized double-blind sham-controlled study.
Latrèche, Caren; Mancini, Valentina; Rochas, Vincent; Maeder, Johanna; Cantonas, Lucia M; Férat, Victor; Schneider, Maude; Michel, Christoph M; Eliez, Stephan.
Afiliación
  • Latrèche C; Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva School of Medicine, Switzerland. Electronic address: caren.latreche@unige.ch.
  • Mancini V; Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva School of Medicine, Switzerland.
  • Rochas V; Functional Brain Mapping Laboratory, Department of Basic Neurosciences, University of Geneva, Switzerland; Human Neuroscience Platform, Fondation Campus Biotech Geneva, Geneva, Switzerland.
  • Maeder J; Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva School of Medicine, Switzerland.
  • Cantonas LM; Autism Brain and Behavior Laboratory, Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland.
  • Férat V; Functional Brain Mapping Laboratory, Department of Basic Neurosciences, University of Geneva, Switzerland.
  • Schneider M; Clinical Psychology Unit for Developmental and Intellectual Disabilities, Faculty of Psychology and Educational Sciences, University of Geneva, Switzerland.
  • Michel CM; Functional Brain Mapping Laboratory, Department of Basic Neurosciences, University of Geneva, Switzerland.
  • Eliez S; Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva School of Medicine, Switzerland; Department of Genetic Medicine and Development, University of Geneva School of Medicine, Switzerland.
Psychiatry Res ; 335: 115835, 2024 May.
Article en En | MEDLINE | ID: mdl-38460352
ABSTRACT
Abnormal cognitive development, particularly working memory (WM) deficits, is among the first apparent manifestations of psychosis. Yet, cognitive impairment only shows limited response to current pharmacological treatment. Alternative interventions to target cognition are highly needed in individuals at high risk for psychosis, like carriers of 22q11.2 deletion syndrome (22q11.2DS). Here we applied theta-tuned transcranial alternating current stimulation (tACS) between frontal and temporal regions during a visual WM task in 34 deletion carriers. We conducted a double-blind sham-controlled study over three consecutive days. The stimulation parameters were derived from individual structural MRI scan and HD-EEG data acquired at baseline (Day 1) to model current intensity and individual preferential theta peak. Participants were randomized to either sham or tACS (Days 2 and 3) and then completed a visual WM task and a control task. Our findings reveal that tACS was safe and well-tolerated among participants. We found a significantly increased accuracy in the visual WM but not the control task following tACS. Moreover, this enhancement in WM accuracy was greater after tACS than during tACS, indicating stronger offline effects than online effects. Our study therefore supports the application of repeated sessions of brain stimulation in 22q11.2DS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de DiGeorge / Disfunción Cognitiva / Estimulación Transcraneal de Corriente Directa Límite: Adolescent / Humans Idioma: En Revista: Psychiatry Res Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de DiGeorge / Disfunción Cognitiva / Estimulación Transcraneal de Corriente Directa Límite: Adolescent / Humans Idioma: En Revista: Psychiatry Res Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda