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Novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and aggressive presentation.
Furtado, Larissa V; Cardenas, Maria; Santiago, Teresa; Ruiz, Robert E; Shi, Zonggao; Pappo, Alberto; Kacar, Marija.
Afiliación
  • Furtado LV; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Cardenas M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Santiago T; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Ruiz RE; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Shi Z; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Pappo A; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Kacar M; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Genes Chromosomes Cancer ; 63(3): e23230, 2024 03.
Article en En | MEDLINE | ID: mdl-38459940
ABSTRACT
Childhood melanoma is a rare and biologically heterogeneous pediatric malignancy. The differential diagnosis of pediatric melanoma is usually broad, including a wide variety of spindle cell or epithelioid neoplasms. Different molecular alterations affecting the MAPK and PI3K/AKT/mTOR pathways, tumor suppressor genes, and telomerase reactivation have been implicated in melanoma tumorigenesis and progression. Here, we report a novel MED15ATF1 fusion in a pediatric melanoma with spitzoid features and an aggressive clinical course.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirroles / Neoplasias Cutáneas / Proteínas de Fusión Oncogénica / Nevo de Células Epitelioides y Fusiformes / Glicina / Melanoma Límite: Child / Humans Idioma: En Revista: Genes Chromosomes Cancer Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirroles / Neoplasias Cutáneas / Proteínas de Fusión Oncogénica / Nevo de Células Epitelioides y Fusiformes / Glicina / Melanoma Límite: Child / Humans Idioma: En Revista: Genes Chromosomes Cancer Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos