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Circadian Variation in the Response to Vaccination: A Systematic Review and Evidence Appraisal.
Wyse, Cathy A; Rudderham, Laura M; Nordon, Enya A; Ince, Louise M; Coogan, Andrew N; Lopez, Lorna M.
Afiliación
  • Wyse CA; Kathleen Lonsdale Institute for Human Health Research and Department of Biology, Maynooth University, Maynooth, Ireland.
  • Rudderham LM; Kathleen Lonsdale Institute for Human Health Research and Department of Biology, Maynooth University, Maynooth, Ireland.
  • Nordon EA; Kathleen Lonsdale Institute for Human Health Research and Department of Biology, Maynooth University, Maynooth, Ireland.
  • Ince LM; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA.
  • Coogan AN; Kathleen Lonsdale Institute for Human Health Research and Department of Psychology, Maynooth University, Maynooth, Ireland.
  • Lopez LM; Kathleen Lonsdale Institute for Human Health Research and Department of Biology, Maynooth University, Maynooth, Ireland.
J Biol Rhythms ; 39(3): 219-236, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38459699
ABSTRACT
Molecular timing mechanisms known as circadian clocks drive endogenous 24-h rhythmicity in most physiological functions, including innate and adaptive immunity. Consequently, the response to immune challenge such as vaccination might depend on the time of day of exposure. This study assessed whether the time of day of vaccination (TODV) is associated with the subsequent immune and clinical response by conducting a systematic review of previous studies. The Cochrane Library, PubMed, Google, Medline, and Embase were searched for studies that reported TODV and immune and clinical outcomes, yielding 3114 studies, 23 of which met the inclusion criteria. The global severe acute respiratory syndrome coronavirus 2 vaccination program facilitated investigation of TODV and almost half of the studies included reported data collected during the COVID-19 pandemic. There was considerable heterogeneity in the demography of participants and type of vaccine, and most studies were biased by failure to account for immune status prior to vaccination, self-selection of vaccination time, or confounding factors such as sleep, chronotype, and shiftwork. The optimum TODV was concluded to be afternoon (5 studies), morning (5 studies), morning and afternoon (1 study), midday (1 study), and morning or late afternoon (1 study), with the remaining 10 studies reporting no effect. Further research is required to understand the relationship between TODV and subsequent immune outcome and whether any clinical benefit outweighs the potential effect of this intervention on vaccine uptake.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunación / Ritmo Circadiano / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 Límite: Humans Idioma: En Revista: J Biol Rhythms Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunación / Ritmo Circadiano / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 Límite: Humans Idioma: En Revista: J Biol Rhythms Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos