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Prophylactic early low-dose hydrocortisone and survival without bronchopulmonary dysplasia among extremely preterm infants born at 22-27 weeks' gestation.
Shah, Sanket D; Shukla, Samarth; Nandula, P Sireesha; Vice, Shannon; Elgendy, Marwa; Gautam, Shiva; Hudak, Mark L; Cortez, Josef.
Afiliación
  • Shah SD; Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA.
  • Shukla S; Division of Neonatology, Advent Health, Orlando, FL, USA.
  • Nandula PS; Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA.
  • Vice S; Department of Pediatrics, University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA.
  • Elgendy M; Department of Pediatrics, University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA.
  • Gautam S; Department of Pediatrics, University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA.
  • Hudak ML; Department of Biostatistics and Department of Pediatrics, University of Florida, Gainesville, FL, USA.
  • Cortez J; Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine Jacksonville, Jacksonville, FL, USA.
J Perinatol ; 44(7): 947-952, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38459373
ABSTRACT

OBJECTIVE:

To compare survival without BPD among extremely preterm infants (EPI) who received prophylactic early low-dose hydrocortisone (PEH) with those who did not (non-PEH). STUDY

DESIGN:

This single-center retrospective study compared risk-adjusted rates of survival without BPD, BPD, bowel perforation, and late-onset sepsis among infants (22-27 weeks' gestation at birth) who received PEH (n = 82) and who did not (n = 205).

RESULTS:

Infants in the PEH group were of lower gestational age, lower birthweight, and higher day-1 risk of death/BPD. After adjusting for risk of death/BPD, PEH-treated infants demonstrated increased survival without BPD (aOR 2.04, 95%CI 1.1-3.7), and lower BPD rates (aOR 0.46, 95%CI 0.25-0.87). Importantly, bowel perforation or sepsis rate were similar among both groups.

CONCLUSION:

After risk adjustment, PEH-treated infants demonstrated improved survival without BPD and did not increase rates of bowel perforation or sepsis. In our cohort of infants, PEH was safe and effective among the sickest preterm neonates.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Displasia Broncopulmonar / Hidrocortisona / Edad Gestacional / Recien Nacido Extremadamente Prematuro Límite: Female / Humans / Male / Newborn Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Displasia Broncopulmonar / Hidrocortisona / Edad Gestacional / Recien Nacido Extremadamente Prematuro Límite: Female / Humans / Male / Newborn Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos