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Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans.
Torigoe, Trevor H; Willcox, D Craig; Shimabukuro, Michio; Higa, Moritake; Gerschenson, Mariana; Andrukhiv, Anastasia; Suzuki, Makoto; Morris, Brian J; Chen, Randi; Gojanovich, Greg S; Allsopp, Richard C; Willcox, Bradley J.
Afiliación
  • Torigoe TH; Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA. trevorht@hawaii.edu.
  • Willcox DC; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Shimabukuro M; Department of Human Welfare, Okinawa International University, Ginowan, Okinawa, Japan.
  • Higa M; Okinawa Research Center for Longevity Science, Urasoe, Okinawa, Japan.
  • Gerschenson M; Department of Research, Kuakini Medical Center, Honolulu, HI, USA.
  • Andrukhiv A; Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
  • Suzuki M; Diabetes and Life-Style Related Disease Center, Tomishiro Central Hospital, Tomishiro, Okinawa, Japan.
  • Morris BJ; Diabetes and Life-Style Related Disease Center, Tomishiro Central Hospital, Tomishiro, Okinawa, Japan.
  • Chen R; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Gojanovich GS; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Allsopp RC; Okinawa Research Center for Longevity Science, Urasoe, Okinawa, Japan.
  • Willcox BJ; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
NPJ Aging ; 10(1): 18, 2024 Mar 08.
Article en En | MEDLINE | ID: mdl-38459055
ABSTRACT
The genetic association of FOXO3 genotypes with human longevity is well established, although the mechanism is not fully understood. We now report on the relationship of the FOXO3 longevity variant rs2802292 with telomere length, telomerase activity, FOXO3 expression, and inflammatory cytokine levels in men and women. In agreement with earlier work, the FOXO3 longevity variant conferred protection against telomere shortening of peripheral blood mononuclear cells from adults aged 55 years and older. This was accompanied by higher levels of telomerase activity in mononuclear cells for carriers of the longevity-associated FOXO3 G-allele of SNP rs2802292 (P = 0.015). FOXO3 mRNA expression increased slightly with age in both young (P = 0.02) and old (P = 0.08) G-allele carriers. Older female G-allele carriers displayed a modest decline in levels of pro-inflammatory cytokine IL-6 with age (P = 0.07). In contrast, older male G-allele carriers displayed an age-dependent increase in levels of anti-inflammatory cytokine IL-10 with age (P = 0.04). Thus, FOXO3 may act through several different pro-longevity mechanisms, which may differ by age and sex.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Aging Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Aging Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido