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M2-type macrophage-targeted delivery of IKKß siRNA induces M2-to-M1 repolarization for CNV gene therapy.
Zhang, Yu; Chu, Baorui; Fan, Qian; Song, Xian; Xu, Qian; Qu, Yi.
Afiliación
  • Zhang Y; Department of Geriatrics, Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China.
  • Chu B; Department of Geriatrics, Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China.
  • Fan Q; Department of Geriatrics, Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China.
  • Song X; Department of Geriatrics, Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China.
  • Xu Q; Department of Geriatrics, Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China.
  • Qu Y; Department of Geriatrics, Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China; Key Laboratory of Cardiovascular Proteomics of Shandong Province, Jinan 250012, China; Jinan Clinical Research Center for Geriatric Medicine (202132001), Jinan 250012, China. Electronic
Nanomedicine ; 57: 102740, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38458368
ABSTRACT
Choroidal Neovascularization (CNV) is capable of inciting recurrent hemorrhage in the macular region, severely impairing patients' visual acuity. During the onset of CNV, infiltrating M2 macrophages play a crucial role in promoting angiogenesis. To control this disease, our study utilizes the RNA interference (RNAi)-based gene therapy to reprogram M2 macrophages to the M1 phenotype in CNV lesions. We synthesize the mannose-modified siRNA-loaded liposome specifically targeting M2 macrophages to inhibit the inhibitory kappa B kinase ß (IKKß) gene involved in the polarization of macrophages, consequently modulating macrophage polarization state. In vitro and in vivo, the mannose-modified IKKß siRNA-loaded liposome (siIKKß-ML) has been proven to effectively target M2 macrophages to repolarize them to M1 phenotype, and inhibit the progression of CNV. Collectively, our findings elucidate that siIKKß-ML holds the potential to control CNV by reprogramming the macrophage phenotype, indicating a promising therapeutic avenue for CNV management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neovascularización Coroidal / Quinasa I-kappa B Límite: Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neovascularización Coroidal / Quinasa I-kappa B Límite: Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos