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Metastatic Tonsil Squamous Cell Carcinoma: An Important Consideration in the Differential Diagnosis of Malignant Basaloid Neoplasms in the Skin: Case Report and Review of the Literature.
Thigpen, Bradley T; Johnston, Ronald B; Giubellino, Alessio; Mogrovejo, Diana O; Jethwa, Ashok R; Patino, Willmar D.
Afiliación
  • Thigpen BT; University of Alabama Marnix E. Heersink School of Medicine, Birmingham, AL.
  • Johnston RB; Forefront Dermatology, Manitowoc, WI; and.
  • Giubellino A; University of Minnesota, Minneapolis, MN.
  • Mogrovejo DO; University of Minnesota, Minneapolis, MN.
  • Jethwa AR; University of Minnesota, Minneapolis, MN.
  • Patino WD; Forefront Dermatology, Manitowoc, WI; and.
Am J Dermatopathol ; 46(8): 514-518, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-38457690
ABSTRACT
ABSTRACT Malignant basaloid neoplasms of the skin are frequent, and their accurate diagnosis holds paramount importance for treatment and prognosis. However, these neoplasms can present diagnostic challenges because of their extensive differential diagnosis, which encompasses cutaneous metastasis among many other possibilities. We present a case of a 74-year-old man with a history of p16-positive palatine tonsil squamous cell carcinoma (SCC) treated with surgery and adjuvant radiation with no prior evidence of recurrence who presented to the dermatologist with 2 chin papules. The initial histopathologic evaluation of these lesions showed poorly differentiated malignant basaloid neoplasms. Subsequently, these biopsies were compared with the previous biopsies from his tonsil and lymph node, which showed similar findings including positive p16 staining and positive molecular testing for human papillomavirus-16, confirming the diagnosis of cutaneous metastasis from his previously diagnosed human papillomavirus-related tonsil SCC. Additional imaging studies found metastases to internal organs including the brain, and he was started on chemotherapy, immunotherapy, and radiation therapy. Cutaneous metastases from tonsil SCC are exceedingly rare, and only 5 cases have been described. Furthermore, this is the first case confirming the presence of high-risk human papillomavirus by molecular studies within the cutaneous metastases. The presented case underscores the importance of recognizing this unusual manifestation of tonsil SCC metastatic to the skin along with a good clinical patient history, ensuring accurate and prompt diagnosis and treatment of this condition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Carcinoma de Células Escamosas / Neoplasias Tonsilares Límite: Aged / Humans / Male Idioma: En Revista: Am J Dermatopathol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Carcinoma de Células Escamosas / Neoplasias Tonsilares Límite: Aged / Humans / Male Idioma: En Revista: Am J Dermatopathol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos