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Neuropeptide W protects against ovarian oxidative injury and reinforces ovarian steroidogenic activity via the upregulation of ERα expression.
Arabaci Tamer, Sevil; Sen, Leyla Semiha; Günes, Kasim; Yüksel, Meral; Çetinel, Sule; Yegen, Berrak Ç.
Afiliación
  • Arabaci Tamer S; Department of Physiology, Marmara University School of Medicine, Istanbul, Türkiye.
  • Sen LS; Department of Physiology, Marmara University School of Medicine, Istanbul, Türkiye.
  • Günes K; Department of Histology and Embryology, Marmara University School of Medicine, Istanbul, Türkiye.
  • Yüksel M; Medical Laboratory Techniques Department, Marmara University Vocational School of Health Sciences, Istanbul, Türkiye.
  • Çetinel S; Department of Histology and Embryology, Marmara University School of Medicine, Istanbul, Türkiye.
  • Yegen BÇ; Department of Physiology, Marmara University School of Medicine, Istanbul, Türkiye.
J Pharm Pharmacol ; 76(6): 606-615, 2024 Jun 06.
Article en En | MEDLINE | ID: mdl-38457354
ABSTRACT

OBJECTIVES:

The aim of this study was to investigate the protective effect of neuropeptide W (NPW) on ovarian ischemia-reperfusion-induced oxidative injury and ovarian steroid metabolism.

METHODS:

Rats were randomly divided into control and ischemia groups that received either saline or NPW (0.1 or 5 µg/kg/day). Bilateral ovarian ischemia was performed for 3 h followed by a 72-h reperfusion. Blood, ovary, and uterus samples were collected for biochemical and histological assessments. KEY

FINDINGS:

Treatment with either dose of NPW alleviated oxidative injury of the ovaries with a significant suppression in free radical formation and decreased histopathological injury in both the ovarian and uterine tissues, along with reduced lipid peroxidation and neutrophil accumulation in the uterus. Moreover, NPW treatment reversed the decrease in aromatase expression with a concomitant reduction in the expression of the inactivity enzyme estrogen sulfotransferase. Also, downregulation of estrogen receptor-α (ERα) expression in the injured ovarian tissue was abolished by NPW treatment, which implicates that the protective effect of NPW on the female reproductive system may involve the upregulation of the ERα-mediated signaling pathway.

CONCLUSIONS:

Our study demonstrated for the first time that NPW protects against ovarian oxidative injury and reinforces ovarian steroidogenic activity, which is accompanied by the upregulation of ERα expression in the ovaries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovario / Daño por Reperfusión / Regulación hacia Arriba / Estrés Oxidativo / Receptor alfa de Estrógeno Límite: Animals Idioma: En Revista: J Pharm Pharmacol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovario / Daño por Reperfusión / Regulación hacia Arriba / Estrés Oxidativo / Receptor alfa de Estrógeno Límite: Animals Idioma: En Revista: J Pharm Pharmacol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido