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Effects of subthalamic nucleus deep brain stimulation using different frequency programming paradigms on axial symptoms in advanced Parkinson's disease.
Cheng, Yifeng; Zhao, Guangrui; Chen, Lei; Cui, Deqiu; Wang, Chunjuan; Feng, Keke; Yin, Shaoya.
Afiliación
  • Cheng Y; Department of Functional Neurosurgery, Huanhu Hospital, Tianjin University, Tianjin, 300350, China.
  • Zhao G; Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, 300350, China.
  • Chen L; Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, 300350, China.
  • Cui D; Department of Neurology, Huanhu Hospital, Tianjin University, Tianjin, 300350, China.
  • Wang C; Department of Functional Neurosurgery, Huanhu Hospital, Tianjin University, Tianjin, 300350, China.
  • Feng K; Department of Functional Neurosurgery, Huanhu Hospital, Tianjin University, Tianjin, 300350, China.
  • Yin S; Department of Functional Neurosurgery, Huanhu Hospital, Tianjin University, Tianjin, 300350, China. tjfengkeke@126.com.
Acta Neurochir (Wien) ; 166(1): 124, 2024 Mar 08.
Article en En | MEDLINE | ID: mdl-38457027
ABSTRACT

BACKGROUND:

In advanced Parkinson's disease (PD), axial symptoms are common and can be debilitating. Although deep brain stimulation (DBS) significantly improves motor symptoms, conventional high-frequency stimulation (HFS) has limited effectiveness in improving axial symptoms. In this study, we investigated the effects on multiple axial symptoms after DBS surgery with three different frequency programming paradigms comprising HFS, low-frequency stimulation (LFS), and variable-frequency stimulation (VFS).

METHODS:

This study involved PD patients who had significant preoperative axial symptoms and underwent bilateral subthalamic nucleus (STN) DBS. Axial symptoms, motor symptoms, medications, and quality of life were evaluated preoperatively (baseline). One month after surgery, HFS was applied. At 6 months post-surgery, HFS assessments were performed, and HFS was switched to LFS. A further month later, we conducted LFS assessments and switched LFS to VFS. At 8 months after surgery, VFS assessments were performed.

RESULTS:

Of the 21 PD patients initially enrolled, 16 patients were ultimately included in this study. Regarding HFS, all axial symptoms except for the Berg Balance Scale (p < 0.0001) did not improve compared with the baseline (all p > 0.05). As for LFS and VFS, all axial symptoms improved significantly compared with both the baseline and HFS (all p < 0.05). Moreover, motor symptoms and medications were significantly better than the baseline (all p < 0.05) after using LFS and VFS. Additionally, the quality of life of the PD patients after receiving LFS and VFS was significantly better than at the baseline and with HFS (all p < 0.0001).

CONCLUSION:

Our findings indicate that HFS is ineffective at improving the majority of axial symptoms in advanced PD. However, both the LFS and VFS programming paradigms exhibit significant improvements in various axial symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Núcleo Subtalámico / Estimulación Encefálica Profunda Límite: Humans Idioma: En Revista: Acta Neurochir (Wien) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Austria
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Núcleo Subtalámico / Estimulación Encefálica Profunda Límite: Humans Idioma: En Revista: Acta Neurochir (Wien) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Austria