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HHV8-Positive Multicentric Castleman's Disease and Thrombotic Thrombocytopenic Purpura among HIV-Positive Patients.
Pasquer, Roxane; Dieudonné, Yannick; Decours, Pauline; Hinschberger, Olivier; Nicolae, Alina; Martinot, Martin.
Afiliación
  • Pasquer R; Clinical Immunology Department, Nouvel Hôpital Civil, Strasbourg University, Strasbourg, France.
  • Dieudonné Y; Clinical Immunology Department, Nouvel Hôpital Civil, Strasbourg University, Strasbourg, France.
  • Decours P; Clinical Immunology Department, Nouvel Hôpital Civil, Strasbourg University, Strasbourg, France.
  • Hinschberger O; Internal Medicine and Clinical Immunology Department, Hôpitaux Civils de Colmar, Colmar, France.
  • Nicolae A; Anatomopathology Laboratory, Nouvel Hôpital Civil, Strasbourg, France.
  • Martinot M; Infectious Diseases Department, Hôpitaux Civils de Colmar, Colmar, France.
Eur J Case Rep Intern Med ; 11(3): 004361, 2024.
Article en En | MEDLINE | ID: mdl-38455701
ABSTRACT
Castleman's disease (CD) and thrombotic thrombocytopenic purpura (TTP) are rare diseases that can affect the general population, especially those with HIV. Owing to their rarity, the association between CD and TTP remains insufficiently understood. In this study, we present a case of a 53-year-old patient with controlled HIV infection who presented with fever, lymphadenopathy, severe anaemia, and thrombocytopenia. After a series of tests, the diagnosis was concurrent human herpesvirus 8 (HHV8)-related multicentric CD (MCD) and TTP. Only four male patients were previously reported having this association, with HHV8 present in four and HIV in three patients, suggesting that coinfection with HHV8 and HIV is a pivotal factor in MCD with TTP occurrence. LEARNING POINTS Castleman's disease (CD) and thrombotic thrombocytopenic purpura (TTP) are rare diseases, and their association remains extremely uncommon.We report a case of multicentric CD (MCD) with TTP in a 53-year-old male patient with HIV.Only five patients, including ours, have been reported as having both MCD and TTP, with all five having HHV8 and four having HIV. Thus, coinfection with HHV8 and HIV may be a potential pivotal factor in the occurrence of MCD with TTP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Case Rep Intern Med Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Case Rep Intern Med Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Italia