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Adipocytokines as Predictors of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Development in Type 2 Diabetes Mellitus Patients.
Fajkic, Almir; Jahic, Rijad; Hadzovic-Dzuvo, Almira; Lepara, Orhan.
Afiliación
  • Fajkic A; Department of Pathophysiology, University of Sarajevo Faculty of Medicine, Sarajevo, BIH.
  • Jahic R; Department of Internal Medicine, General Hospital "Prim. Dr. Abdulah Nakas", Sarajevo, BIH.
  • Hadzovic-Dzuvo A; Department of Human Physiology, University of Sarajevo Faculty of Medicine, Sarajevo, BIH.
  • Lepara O; Department of Human Physiology, University of Sarajevo Faculty of Medicine, Sarajevo, BIH.
Cureus ; 16(3): e55673, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38455340
ABSTRACT

BACKGROUND:

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver condition. Due to pathophysiological processes, MASLD's relation to type 2 diabetes mellitus (T2DM) is still unclear, especially when the role of adipocytokines is taken into consideration.

OBJECTIVE:

This study aims to examine the potential predictive value of adiponectin and resistin for MASLD in T2DM. PATIENTS AND

METHODS:

In a two-year study, 71 T2DM patients were categorized into MASLD-T2DM and non-MASLD-T2DM groups according to MASLD development. Serum samples were tested for resistin, adiponectin, high-density lipoprotein cholesterol, fasting glucose, and triglycerides. An appropriate equation is used to calculate the adiponectin/resistin (A/R) index. The optimal cut-off values for differentiating MASLD patients from non-MASLD patients were determined using receiver operating characteristic (ROC) curves and the corresponding areas under the curve (AUC). To predict the onset of MASLD in patients with T2DM, a logistic regression analysis was performed.

RESULTS:

There were significant differences in adiponectin (p<0.001), resistin (p<0.001), and A/R index (p<0.001) between T2DM individuals with and without MASLD. The ROC curve for resistin produced an AUC of 0.997 (p<0.001) with a sensitivity of 96.1% and a specificity of 100% for the cut-off point of 253.15. Adiponectin (OR, 0.054; 95% CI, 0.011-0.268; p<0.001) and resistin (OR, 1.745; 95% CI, 1.195-2,548; p=0.004) were found to be independent predictors for MASLD by logistic regression analysis.

CONCLUSION:

This study confirms the potential of adiponectin and resistin as predictors of MASLD development in T2DM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos