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Histological and morphological development of the prepuce from birth to prepubertal age.
Erdem, Erim; Caliskan, Mustafa Kaplan; Karagul, Meryem Ilkay; Akbay, Erdem; Coskun Yilmaz, Banu; Aygun, Yuksel Cem.
Afiliación
  • Erdem E; Department of Urology, Mersin University Faculty of Medicine, Mersin, Türkiye.
  • Caliskan MK; Department of Urology, Mersin University Faculty of Medicine, Mersin, Türkiye.
  • Karagul MI; Department of Histology and Embryology, Hatay Mustafa Kemal University Faculty of Medicine, Hatay, Türkiye. ilkaykaragul@gmail.com.
  • Akbay E; Department of Urology, Mersin University Faculty of Medicine, Mersin, Türkiye.
  • Coskun Yilmaz B; Department of Histology and Embryology, Mersin University Faculty of Medicine, Mersin, Türkiye.
  • Aygun YC; Department of Urology, Baskent University Faculty of Medicine, Ankara, Türkiye.
Investig Clin Urol ; 65(2): 180-188, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38454828
ABSTRACT

PURPOSE:

To study the histological changes of the preputial tissue from birth to prepubertal age in order to define unnoticed morphological changes. MATERIALS AND

METHODS:

Prepuce samples were obtained from 79 healthy boys who underwent routine ritual circumcision. Specimens were divided into six groups according to the boys' age newborn, 0-1 year of age, 2-3 years of age, 4-5 years of age, 6-7 years of age, and 8-9 years of age. Histologic analysis of the specimens was performed by H&E, Masson's trichrome, Verhoeff-Von Gieson, immunohistochemical staining.

RESULTS:

Microscopic examinations showed that average epithelial thickness increased after the neonatal period (p=0.001). When collagen fiber density was evaluated, no significant differences between groups were found (p=0.083). When the elastic fibers in the dermis were evaluated, it was determined that the number and thickness of elastic fibers increased with age. Immunohistochemical examinations showed that the number of peripheral nerves marked with S100 was lower in the neonatal period than at other ages (p=0.048). When the vessels marked with CD105 antibody were counted, there was no significant difference between the groups (p=0.078).

CONCLUSIONS:

This is the first study to examine the age-related structure of connective tissue elements in the foreskin. Our results showed that the prepuce's prepubertal maturation process is continuous, and the first 2 years of life are appropriate not only in relation to the physiological effects of age but also the optimum structural changes for wound healing, such as vessel diameter, epithelium thickness, peripheral nerve count.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Circuncisión Masculina / Prepucio Límite: Child / Child, preschool / Humans / Infant / Male / Newborn Idioma: En Revista: Investig Clin Urol Año: 2024 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Circuncisión Masculina / Prepucio Límite: Child / Child, preschool / Humans / Infant / Male / Newborn Idioma: En Revista: Investig Clin Urol Año: 2024 Tipo del documento: Article Pais de publicación: Corea del Sur