Your browser doesn't support javascript.
loading
Factors associated with acute anterior uveitis history in patients with axial spondyloarthritis: Results of a longitudinal study.
Cinakli, Haluk; Ediboglu, Elif Durak; Solmaz, Dilek; Akar, Servet.
Afiliación
  • Cinakli H; Division of Rheumatology, Kirklareli Education and Research Hospital, Kirklareli, Turkey.
  • Ediboglu ED; Division of Rheumatology, Hatay Education and Research Hospital, Hatay, Turkey.
  • Solmaz D; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey.
  • Akar S; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey.
Int J Rheum Dis ; 27(3): e15076, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38454194
ABSTRACT
BACKGROUNDS Acute anterior uveitis (AAU) is the most common extra-musculoskeletal manifestation in axial spondyloarthritis (axSpA).

OBJECTIVES:

The aim of the study is to evaluate the factors associated with AAU attacks in patients with axSpA during a 36-month follow-up period.

METHODS:

In total, 469 patients with axSpA were included in this observational study. Demographic data, clinical characteristics, disease activity measurements, and treatment patterns were compared between patients with and without a history of AAU. The development of AAU and its related factors were investigated using generalized estimating equations, which is a technique for longitudinal data analysis.

RESULTS:

Overall, 99 (21%) out of 469 patients experienced at least one AAU attack, with 77 patients (78%) having a history of AAU and 53 patients (58% of whom had a history of AAU) experiencing AAU attacks during the follow-up period. At baseline, patients with a history of AAU were found to be older (p = .001), be more likely to have peripheral arthritis (p < .001), have higher serum CRP levels (p = .016), have a higher frequency of sulfasalazine (SLZ) and tumor necrosis factor inhibitors (TNFi) use (p < .001 and p < .001, respectively). In the longitudinal analysis, having a history of AAU was identified as the only independent determinant of the development of AAU.

CONCLUSIONS:

AAU history might be a risk factor for the development of AAU attacks in patients with axSpA. Although TNFi and SLZ were prescribed more frequently to patients with a history of AAU, the effectiveness of these agents in preventing further AAU attacks was not demonstrated.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Uveítis Anterior / Espondiloartritis / Espondiloartritis Axial Límite: Humans Idioma: En Revista: Int J Rheum Dis Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Uveítis Anterior / Espondiloartritis / Espondiloartritis Axial Límite: Humans Idioma: En Revista: Int J Rheum Dis Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido