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Rapid point-of-care test for diagnosis of peritonitis in peritoneal dialysis patients.
Htay, Htay; Choo, Jason Chon Jun; Huang, Dorothy Hannah; Jayaballa, Mathini; Johnson, David W; Koniman, Riece; Oei, Elizabeth Ley; Suai, Tan Chieh; Wu, Sin Yan; Foo, Marjorie Wai Yin.
Afiliación
  • Htay H; Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
  • Choo JCJ; DUKE-NUS Medical School, Singapore, Singapore.
  • Huang DH; Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
  • Jayaballa M; DUKE-NUS Medical School, Singapore, Singapore.
  • Johnson DW; Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
  • Koniman R; Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
  • Oei EL; DUKE-NUS Medical School, Singapore, Singapore.
  • Suai TC; Department of Nephrology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
  • Wu SY; Centre for Kidney Disease Research, University of Queensland, Brisbane, QLD, Australia.
  • Foo MWY; Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
Perit Dial Int ; : 8968608241234728, 2024 Mar 07.
Article en En | MEDLINE | ID: mdl-38453893
ABSTRACT

BACKGROUND:

Periplex® is a rapid point-of-care test based on the detection of interleukin-6 (IL-6) or matrix metalloproteinase-8 (MMP-8) to diagnose peritonitis in peritoneal dialysis (PD) patients.

METHODS:

This single-centre study was conducted in Singapore General Hospital from 2019 to 2022. The study recruited PD patients suspected of having peritonitis. Periplex was performed at the presentation and recovery of peritonitis. Primary outcomes were sensitivity and specificity of Periplex at presentation. The positive and negative predictive values of tests were also performed.

RESULTS:

A total of 120 patients were included in the study. The mean age was 60.9 ± 14.9 years, 53% were male, 79% were Chinese and 47.5% had diabetes mellitus. Periplex was positive in all patients with peritonitis (n = 114); sensitivity of 100%; 95% confidence interval (CI) 100-100%. Periplex was falsely positive in three patients with non-infective eosinophilic peritonitis, resulting in a low specificity of 50%; 95% CI 41.1-59.0%. Periplex had a positive predictive value of 97.4% and a negative predictive value of 100%. During recovery from peritonitis, Periplex had high specificity (93.6%) and negative predictive value (98.7%) to indicate the resolution of infection. MMP-8 was more sensitive than IL-6 in detecting peritonitis. Periplex was positive in all patients with peritonitis regardless of the types of PD solutions used.

CONCLUSIONS:

Periplex had high sensitivity, and positive and negative predictive values in the diagnosis of peritonitis can be considered as a screening tool for peritonitis. Given its high specificity and negative predictive value, it may also be used to document the resolution of peritonitis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Perit Dial Int Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Perit Dial Int Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos