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Food insecurity is a risk factor for metabolic dysfunction-associated steatotic liver disease in Latinx children.
Maxwell, Sarah L; Price, Jennifer C; Perito, Emily R; Rosenthal, Philip; Wojcicki, Janet M.
Afiliación
  • Maxwell SL; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.
  • Price JC; Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Perito ER; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.
  • Rosenthal P; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Wojcicki JM; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.
Pediatr Obes ; 19(6): e13109, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38453472
ABSTRACT

INTRODUCTION:

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease among US children. Studies have associated food insecurity with MASLD in adults, but there are few studies of pediatric MASLD, particularly in high-risk populations. We assessed the impact of household food insecurity at 4 years of age on MASLD in Latinx children.

METHODS:

Using a prospective cohort design, Latina mothers were recruited during pregnancy and followed with their children until early to mid-childhood. Our primary exposure was household food insecurity at 4 years of age measured using the validated US Household Food Security Food Module. Our primary outcome, MASLD, was defined as alanine transaminase (ALT) ≥95th% for age/gender plus body mass index (BMI) ≥85% at time of ALT measurement (assessed between ages 5-12). We used multivariable logistic regression models to test for independent associations between household food insecurity and pediatric MASLD.

RESULTS:

Among 136 children, 28.7% reported household food insecurity at 4 years of age and 27.2% had MASLD in early to middle childhood. Approximately 49% of children with MASLD and 21% of children without MASLD were food insecure (p < 0.01). Exposure to household food insecurity at age 4 was independently associated with a 3.7-fold higher odds of MASLD later in childhood (95% CI 1.5-9.0, p < 0.01).

CONCLUSIONS:

Exposure to household food insecurity at 4 years of age was associated with increased risk for MASLD later in childhood. Further studies are needed to explore mechanism(s) and impact of reducing food insecurity on risk for MASLD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hispánicos o Latinos / Inseguridad Alimentaria Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Pediatr Obes Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hispánicos o Latinos / Inseguridad Alimentaria Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Pediatr Obes Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido