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Ambient air pollution and hypertensive disorders of pregnancy in Rome.
Pedersen, Marie; Nobile, Federica; Stayner, Leslie Thomas; de Hoogh, Kees; Brandt, Jørgen; Stafoggia, Massimo.
Afiliación
  • Pedersen M; Department of Epidemiology, Lazio Region Health Service/ASL Roma, Rome, Italy. Electronic address: mp@sund.ku.dk.
  • Nobile F; Department of Epidemiology, Lazio Region Health Service/ASL Roma, Rome, Italy; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Stayner LT; Division of Epidemiology and Biostatistics, University of Illiois, Chicago, Il, USA.
  • de Hoogh K; The Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
  • Brandt J; Department of Environmental Science, Aarhus University, Roskilde, Denmark.
  • Stafoggia M; Department of Epidemiology, Lazio Region Health Service/ASL Roma, Rome, Italy; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Environ Res ; 251(Pt 1): 118630, 2024 Jun 15.
Article en En | MEDLINE | ID: mdl-38452913
ABSTRACT

BACKGROUND:

Ambient air pollution has been associated with hypertensive disorders of pregnancy (HDP), but few studies rely on assessment of fine-scale variation in air quality, specific subtypes and multi-pollutant exposures.

AIM:

To study the impact of long-term exposure to individual and mixture of air pollutants on all and specific subtypes of HDP.

METHODS:

We obtained data from 130,470 liveborn singleton pregnacies in Rome during 2014-2019. Spatiotemporal land-use random-forest models at 1 km spatial resolution assigned to the maternal residential addresses were used to estimate the exposure to particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), and ozone (O3).

RESULTS:

For PM2.5, PM10 and NO2, there was suggestive evidence of increased risk of preeclampsia (PE, n = 442), but no evidence of increased risk for all subtypes of HDP (n = 2297) and gestational hypertension (GH, n = 1901). For instance, an interquartile range of 7.0 µg/m3 increase in PM2.5 exposure during the first trimester of pregnancy was associated with an odds ratio (OR) of 1.06 (95% confidence interval 0.81, 1.39) and 1.04 (0.92, 1.17) after adjustment for NO2 and the corresponding results for a 15.7 µg/m3 increase in NO2 after adjustment for PM2.5 were 1.11 (0.92, 1.34) for PE and 0.83 (0.76, 0.90) for HDP. Increased risks for HDP and GH were suggested for O3 in single-pollutant models and for PM after adjustment for NO2, but all other associations were stable or attenuated in two-pollutant models.

CONCLUSIONS:

The results of our study suggest that PM2.5, PM10 and NO2 increases the risk of PE and that these effects are robust to adjustment for O3 while the increased risks for GH and HDP suggested for O3 attenuated after adjustment for PM or NO2. Additional studies are needed to evaluate the effects of source-specific component of PM on subtypes as well as all types of HDP which would help to target preventive actions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ozono / Hipertensión Inducida en el Embarazo / Contaminantes Atmosféricos / Contaminación del Aire / Material Particulado / Dióxido de Nitrógeno Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Environ Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ozono / Hipertensión Inducida en el Embarazo / Contaminantes Atmosféricos / Contaminación del Aire / Material Particulado / Dióxido de Nitrógeno Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Environ Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos