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Beyond the genome: MALAT1's role in advancing urologic cancer care.
Imran, Mohd; Eltaib, Lina; Siddique, Muhammad Irfan; Kamal, Mehnaz; Asdaq, Syed Mohammed Basheeruddin; Singla, Neelam; Al-Hajeili, Marwan; Alhakami, Fatemah Abdulaziz; AlQarni, Ahmed Farhan; Abdulkhaliq, Altaf A; Rabaan, Ali A.
Afiliación
  • Imran M; Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia. Electronic address: imran.pchem10@outlook.com.
  • Abida; Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
  • Eltaib L; Department of Pharmaceutics, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
  • Siddique MI; Department of Pharmaceutics, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
  • Kamal M; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
  • Asdaq SMB; Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh 13713, Saudi Arabia.
  • Singla N; School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur 302017, India.
  • Al-Hajeili M; Department of Medicine, King Abdulaziz University, Jeddah 23624, Saudi Arabia.
  • Alhakami FA; Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Saudi Arabia.
  • AlQarni AF; Histopathology Laboratory, Najran Armed Forces Hospital, Najran 66251, Saudi Arabia.
  • Abdulkhaliq AA; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
  • Rabaan AA; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia; Department of Public Health and Nutrition, The University of Haripur, Haripur 22610, Pakistan.
Pathol Res Pract ; 256: 155226, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38452585
ABSTRACT
Urologic cancers (UCs), which include bladder, kidney, and prostate tumors, account for almost a quarter of all malignancies. Long non-coding RNAs (lncRNAs) are tissue-specific RNAs that influence cell growth, death, and division. LncRNAs are dysregulated in UCs, and their abnormal expression may allow them to be used in cancer detection, outlook, and therapy. With the identification of several novel lncRNAs and significant exploration of their functions in various illnesses, particularly cancer, the study of lncRNAs has evolved into a new obsession. MALAT1 is a flexible tumor regulator implicated in an array of biological activities and disorders, resulting in an important research issue. MALAT1 appears as a hotspot, having been linked to the dysregulation of cell communication, and is intimately linked to cancer genesis, advancement, and response to treatment. MALAT1 additionally operates as a competitive endogenous RNA, binding to microRNAs and resuming downstream mRNA transcription and operation. This regulatory system influences cell growth, apoptosis, motility, penetration, and cell cycle pausing. MALAT1's evaluation and prognosis significance are highlighted, with a thorough review of its manifestation levels in several UC situations and its association with clinicopathological markers. The investigation highlights MALAT1's adaptability as a possible treatment target, providing fresh ways for therapy in UCs as we integrate existing information The article not only gathers current knowledge on MALAT1's activities but also lays the groundwork for revolutionary advances in the treatment of UCs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Urológicas / MicroARNs / ARN Largo no Codificante Límite: Humans / Male Idioma: En Revista: Pathol Res Pract Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Urológicas / MicroARNs / ARN Largo no Codificante Límite: Humans / Male Idioma: En Revista: Pathol Res Pract Año: 2024 Tipo del documento: Article Pais de publicación: Alemania