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Smartphone-assisted hydrogel platform based on BSA-CeO2 nanoclusters for dual-mode determination of acetylcholinesterase and organophosphorus pesticides.
Dai, Yin; Xu, Wei; Wen, Xinyi; Fan, Huizhu; Zhang, Qing; Zhang, Jun; Zhang, Hongsong; Zhu, Wanying; Hong, Junli.
Afiliación
  • Dai Y; School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
  • Xu W; Jiangsu Provincial Hospital of Chinese Medicine, Nanjing, 210004, Jiangsu, China.
  • Wen X; School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
  • Fan H; School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
  • Zhang Q; School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
  • Zhang J; School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
  • Zhang H; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.
  • Zhu W; School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
  • Hong J; School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu, China. junlihong@njmu.edu.cn.
Mikrochim Acta ; 191(4): 185, 2024 03 07.
Article en En | MEDLINE | ID: mdl-38451330
ABSTRACT
A dual-mode sensor was developed for detecting acetylcholinesterase (AChE) and organophosphorus pesticides (OPs) via bifunctional BSA-CeO2 nanoclusters (NCs) with oxidase-mimetic activity and fluorescence property. The dual-mode sensor has the characteristics of self-calibration and self-verification, meeting the needs of different detection conditions and provide more accurate results. The colorimetric sensor and fluorescence sensor have been successfully used for detecting AChE with limit of detection (LOD) of 0.081 mU/mL and 0.056 mU/mL, respectively, while the LOD for OPs were 0.9 ng/mL and 0.78 ng/mL, respectively. The recovery of AChE was 93.9-107.2% and of OPs was 95.8-105.0% in actual samples. A novel strategy was developed to monitor pesticide residues and detect AChE level, which will motivate future work to explore the potential applications of multifunctional nanozymes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaguicidas / Acetilcolinesterasa / Técnicas de Química Analítica / Teléfono Inteligente Idioma: En Revista: Mikrochim Acta Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Austria

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaguicidas / Acetilcolinesterasa / Técnicas de Química Analítica / Teléfono Inteligente Idioma: En Revista: Mikrochim Acta Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Austria