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Medically unexplained symptoms are common in women in tertiary neurological healthcare center: A survey cohort study of persons investigated for suspected multiple sclerosis.
Novakova, Lenka; Hedström, Anna Karin; Axelsson, Markus; Brandt, Anne Frandsen; Alfredsson, Lars; Olsson, Tomas; Lycke, Jan.
Afiliación
  • Novakova L; Department of Clinical Neuroscience, Institute of Neuscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Hedström AK; Department of Neurology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Axelsson M; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
  • Brandt AF; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Alfredsson L; Department of Clinical Neuroscience, Institute of Neuscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Olsson T; Department of Neurology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Lycke J; Department of Clinical Neuroscience, Institute of Neuscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Brain Behav ; 14(3): e3459, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38451005
ABSTRACT

BACKGROUND:

A significant proportion of individuals with suspicious onset of multiple sclerosis (MS) does not fulfill the diagnostic criteria. Although some receive other diagnoses, many remain undiagnosed and lack healthcare follow-up. This study aimed to characterize persons with undetermined diagnosis (PwUD) through a questionnaire.

METHODS:

Incident cases with suspected MS were consecutively admitted to a tertiary neurological healthcare center in a prospective cohort study. Those who remained undiagnosed after 40 months (mean, range 31-52) were considered PwUD. They completed a modified questionnaire, previously used in a population-based case-control study of incident MS cases. Their responses were compared with two control cohorts, persons with MS (PwMS) and healthy controls, randomly selected from national registries, matched by age, gender, and area of residence.

RESULTS:

Out of 271 patients with suspected MS onset, 72 (20.3%) were PwUD with a female majority (79%). The response rate was 83% and 39% reported persisting MS-like symptoms. Compared to controls (n = 548) and PwMS (n = 277), fewer PwUD were currently smoking (p = .4 and p = .03), consumed less alcohol (p = .04 and p = .01), and had children (p = .02 and p = .002). PwUD reported occurrence of other autoimmune disease in 29%, higher compared to PwMS and controls (p < .001 and p < .001).

CONCLUSIONS:

UD is common among persons investigated for suspected MS, in particular among female parents. Our data suggest that PwUD can be characterized as nonsmokers with low alcohol consumption and a higher prevalence of autoimmune disease, in particular thyroid disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Síntomas sin Explicación Médica / Esclerosis Múltiple Límite: Child / Female / Humans Idioma: En Revista: Brain Behav Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Síntomas sin Explicación Médica / Esclerosis Múltiple Límite: Child / Female / Humans Idioma: En Revista: Brain Behav Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos