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Wolbachia strain wAlbB shows favourable characteristics for dengue control use in Aedes aegypti from Burkina Faso.
Mancini, Maria Vittoria; Murdochy, Shivan M; Bilgo, Etienne; Ant, Thomas H; Gingell, Daniel; Gnambani, Edounou Jacques; Failloux, Anna-Bella; Diabate, Abdoulaye; Sinkins, Steven P.
Afiliación
  • Mancini MV; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Murdochy SM; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
  • Bilgo E; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Ant TH; Institut de Recherche en Sciences de la Santé, Direction Régionale de l'Ouest, Dioulasso, Burkina Faso.
  • Gingell D; Institut National de Santé Publique/Centre Muraz, Dioulasso, Burkina Faso.
  • Gnambani EJ; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Failloux AB; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Diabate A; Institut de Recherche en Sciences de la Santé, Direction Régionale de l'Ouest, Dioulasso, Burkina Faso.
  • Sinkins SP; Institut National de Santé Publique/Centre Muraz, Dioulasso, Burkina Faso.
Environ Microbiol ; 26(3): e16588, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38450576
ABSTRACT
Dengue represents an increasing public health burden worldwide. In Africa, underreporting and misdiagnosis often mask its true epidemiology, and dengue is likely to be both more widespread than reported data suggest and increasing in incidence and distribution. Wolbachia-based dengue control is underway in Asia and the Americas but has not to date been deployed in Africa. Due to the genetic heterogeneity of African Aedes aegypti populations and the complexity of the host-symbiont interactions, characterization of key parameters of Wolbachia-carrying mosquitoes is paramount for determining the potential of the system as a control tool for dengue in Africa. The wAlbB Wolbachia strain was stably introduced into an African Ae. aegypti population by introgression, and showed high intracellular density in whole bodies and different mosquito tissues; high intracellular density was also maintained following larval rearing at high temperatures. No effect on the adult lifespan induced by Wolbachia presence was detected. Moreover, the ability of this strain to strongly inhibit DENV-2 dissemination and transmission in the host was also demonstrated in the African background. Our findings suggest the potential of harnessing Wolbachia for dengue control for African populations of Ae. aegypti.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aedes / Wolbachia / Dengue Límite: Animals País/Región como asunto: Africa / Asia Idioma: En Revista: Environ Microbiol Asunto de la revista: MICROBIOLOGIA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aedes / Wolbachia / Dengue Límite: Animals País/Región como asunto: Africa / Asia Idioma: En Revista: Environ Microbiol Asunto de la revista: MICROBIOLOGIA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido