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Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease.
Cheng, Bichu; Wang, Qi; An, Yi; Chen, Fener.
Afiliación
  • Cheng B; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China. rfchen@fudan.edu.cn.
  • Wang Q; School of Science, Green Pharmaceutical Engineering Research Center, Harbin Institute of Technology, Shenzhen 518055, China.
  • An Y; School of Science, Green Pharmaceutical Engineering Research Center, Harbin Institute of Technology, Shenzhen 518055, China.
  • Chen F; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China. rfchen@fudan.edu.cn.
Nat Prod Rep ; 41(7): 1060-1090, 2024 Jul 17.
Article en En | MEDLINE | ID: mdl-38450550
ABSTRACT
Covering 2006 to 2023(-)-Galantamine is a natural product with distinctive structural features and potent inhibitory activity against acetylcholine esterase (AChE). It is clinically approved for the treatment of Alzheimer's disease. The clinical significance and scarcity of this natural product have prompted extensive and ongoing efforts towards the chemical synthesis of this challenging tetracyclic structure. The objective of this review is to summarize and discuss recent progress in the total synthesis of galantamine from 2006 to 2023. The contents are organized according to the synthetic strategies for the construction of the quaternary center. Key features of each synthesis have been highlighted, followed by a summary and outlook at the end.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Inhibidores de la Colinesterasa / Enfermedad de Alzheimer / Galantamina Límite: Humans Idioma: En Revista: Nat Prod Rep Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Inhibidores de la Colinesterasa / Enfermedad de Alzheimer / Galantamina Límite: Humans Idioma: En Revista: Nat Prod Rep Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido