Your browser doesn't support javascript.
loading
Processed Polygonatum cyrtonema Hua attenuates postpartum depression in rat model by regulating monoamines and hormones.
Zhu, Xiao-Hong; Zhang, Jia-Li; Li, De-Hua; Wang, Zhong-Qiang; Liu, Yan-Ku; Fan, Jing-Xian; Jiang, Shang-Ren; Li, Xin-Ran; He, Xian-Yuan.
Afiliación
  • Zhu XH; College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
  • Zhang JL; College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
  • Li DH; College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
  • Wang ZQ; College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
  • Liu YK; Discipline of Pediatrics, Chongqing Medical University, Chongqing, China.
  • Fan JX; College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
  • Jiang SR; Discipline of Pediatrics, Chongqing Medical University, Chongqing, China.
  • Li XR; Key Laboratory of Metabolism and Metabolism of Traditional Chinese Medicine in Chongqing, Chongqing Medical University, Chongqing, China.
  • He XY; Key Laboratory of Metabolism and Metabolism of Traditional Chinese Medicine in Chongqing, Chongqing Medical University, Chongqing, China.
Heliyon ; 10(5): e26895, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38449668
ABSTRACT

Background:

Polygonatum cyrtonema Hua is a traditional Chinese medicinal food herb which can regulate the liver and Qi, nourish the heart and blood, moisten the lungs and nourish the kidneys with the potential to treat emotional diseases. However, few studies have explored the effects of Polygonatum cyrtonema Hua on postpartum depression. Therefore, we investigated whether processed Polygonatum cyrtonema Hua could improve postpartum depression in rat models by regulating monoamines and hormones.

Methods:

Female Sprague-Dawley rats were randomized into normal control (0.9%Nacl), Sham operation (0.9%Nacl), postpartum depression model (0.9%Nacl), fluoxetine (2.5 mg/kg Fluoxetine), low, medium and high dose of processed Polygonatum cyrtonema Hua (2.5 g/kg, 5 g/kg, 10 g/kg) groups. Rats in these groups received drug intervention, and then subjected to Open-field test and Forced swimming test. Brain tissues and serum samples were collected and used to quantify levels of monoamines, hypothalamic-pituitary-adrenal axis and serum Estradiol. The status of neuronal cells in hippocampus 1 region was examined through hematoxylin-eosin staining, whereas expression of estrogen receptor α and ß was detected by immunohistochemistry.

Results:

Rats in the model group showed decreased mobility time, the disorder of neuronal cells in hippocampus 1 area, and decreased concentration of 5-hydroxytryptamine and dopamine in brain tissue, norepinephrine and estradiol in serum as well as estrogen receptor α and ß expression. They also exhibited increased adrenocorticotropic hormone, corticosterone and corticotropin releasing hormone in serum. However, the treatment with processed Polygonatum cyrtonem Hua or fluoxetine reversed the above abnormalities.

Conclusion:

The H group showed significant improvement in postpartum depression in rats, and processed Polygonatum cyrtonema Hua can be used as a developing drug for the prevention or treatment of depression.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido