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Novel near-infrared BODIPY-cyclodextrin complexes for photodynamic therapy.
Lu, Bowei; Lu, Xu; Mu, Manman; Meng, Shuxian; Feng, Yaqing; Zhang, Yi.
Afiliación
  • Lu B; School of Chemical Engineering and Technology, Institute of Molecular Plus, Tianjin University, Tianjin, China.
  • Lu X; Ministry of Health and Medical, General Hospital of Tianjin Medical University, Tianjin, China.
  • Mu M; School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, China.
  • Meng S; School of Chemical Engineering and Technology, Institute of Molecular Plus, Tianjin University, Tianjin, China.
  • Feng Y; School of Chemical Engineering and Technology, Institute of Molecular Plus, Tianjin University, Tianjin, China.
  • Zhang Y; School of Chemical Engineering and Technology, Institute of Molecular Plus, Tianjin University, Tianjin, China.
Heliyon ; 10(5): e26907, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38449663
ABSTRACT
To meet the requirements of diagnosis and treatment, photodynamic therapy (PDT) is a promising cancer treatment with less side-effect. A series of novel BODIPY complexes (BODIPY-CDs) served as PDT agents were first reported to enhance the biocompatibility and water solubility of BODIPY matrix through the click reaction of alkynyl-containing BODIPY and azide-modified cyclodextrin (CD). BODIPY-CDs possessed superior water solubility due to the introduction of CD and their fluorescence emission apparently redshifted (>90 nm) on account of triazole units as the linkers compared to alkynyl-containing BODIPY. Moreover, all the BODIPY-CDs were no cytotoxicity toward NIH 3T3 in different drug concentrations from 12.5 to 200 µg/mL, and had a certain inhibitory effect on tumor HeLa cells. Particularly, BODIPY-ß-CD exhibited high reactive oxygen species generation and excellent photodynamic therapy activity against HeLa cells compared to other complexes. The cell viability of BODIPY-ß-CD was dramatically reduced up to 20% in the concentration of 100 µg/mL upon 808 nm laser irradiation. This architecture might provide a new opportunity to develop valuable photodynamic therapy agents for tumor cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido