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Enhancing Adhesion of Fibrin-Based Hydrogel to Polythioether Polymer Surfaces.
Al Enezy-Ulbrich, Miriam Aischa; Kreuels, Klaus; Simonis, Marc; Milvydaite, Indre; Reineke, Anna Theresa; Schemmer, Carina; Gillner, Arnold; Pich, Andrij.
Afiliación
  • Al Enezy-Ulbrich MA; Institute for Technical and Macromolecular Chemistry, Functional and Interactive Polymers, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany.
  • Kreuels K; DWI - Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstraße 50, 52074 Aachen, Germany.
  • Simonis M; Chair for Laser Technology LLT, RWTH Aachen University, Steinbachstraße 15, 52074 Aachen, Germany.
  • Milvydaite I; Institute for Technical and Macromolecular Chemistry, Functional and Interactive Polymers, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany.
  • Reineke AT; DWI - Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstraße 50, 52074 Aachen, Germany.
  • Schemmer C; Institute for Technical and Macromolecular Chemistry, Functional and Interactive Polymers, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany.
  • Gillner A; DWI - Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstraße 50, 52074 Aachen, Germany.
  • Pich A; Chair for Laser Technology LLT, RWTH Aachen University, Steinbachstraße 15, 52074 Aachen, Germany.
ACS Appl Mater Interfaces ; 16(11): 14371-14381, 2024 Mar 20.
Article en En | MEDLINE | ID: mdl-38445533
ABSTRACT
The development of stable (bio)hybrid constructs composed of scaffolds and (bio)matrices is a major challenge in the field of tissue engineering. In the present work, the adhesion of fibrin-based hydrogels to the surface of polythioether-based polymers relevant to the 3D printing of polymer scaffolds produced by thiol-ene click chemistry was investigated. Adhesion properties were characterized by single-lap tensile shear testing. Both the sample preparation and the test method were optimized for the analysis of fibrin gel bonding to the polythioether surface. Our experimental results show that even without further modification, an adhesion between the fibrin hydrogel and polythioether is substantial, with an adhesion strength of 4.9 ± 1.0 kPa. To further improve the bonding, linear functional poly(N-vinylpyrrolidone-co-glycidyl methacrylate) (PVP-co-GMA) copolymers were used that are known for covalently binding to fibrin. The maximum adhesion strength in our study was found to be 18.4 ± 3.4 kPa. The pure PVP-co-GMA copolymers also demonstrate covalent binding to the thiol-ene-based polymers with a maximum adhesion strength of 32.2 ± 2.7 kPa. Therefore, compared to pure fibrin, the presence of copolymer coating both on the polythioether surface and in the fibrin gel led to a significant increase of the adhesion strength by a factor of 1.6.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrina / Hidrogeles Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrina / Hidrogeles Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos