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A health technology assessment of personalized nutrition interventions using the EUnetHTA HTA Core Model.
Galekop, Milanne Maria Johanna; Del Bas, Josep Maria; Calder, Philip C; Uyl-De Groot, Carin A; Redekop, William Ken.
Afiliación
  • Galekop MMJ; Erasmus School of Health, Policy and Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.
  • Del Bas JM; Eurecat Centre Tecnològic de Catalunya, Biotechnology Area, Reus, Spain.
  • Calder PC; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Uyl-De Groot CA; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK.
  • Redekop WK; Erasmus School of Health, Policy and Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Int J Technol Assess Health Care ; 40(1): e15, 2024 Mar 06.
Article en En | MEDLINE | ID: mdl-38444327
ABSTRACT

OBJECTIVES:

Poor nutrition links to chronic diseases, emphasizing the need for optimized diets. The EU-funded project PREVENTOMICS, introduced personalized nutrition to address this. This study aims to perform a health technology assessment (HTA) comparing personalized nutrition interventions developed through this project, with non-personalized nutrition interventions (control) for people with normal weight, overweight, or obesity. The goal is to support decisions about further development and implementation of personalized nutrition.

METHODS:

The PREVENTOMICS interventions were evaluated using the European Network for HTA Core Model, which includes a methodological framework that encompasses different domains for value assessment. Information was gathered via [1] different statistical analyses and modeling studies, [2] questions asked of project partners and, [3] other (un)published materials.

RESULTS:

Clinical trials of PREVENTOMICS interventions demonstrated different body mass index changes compared to control; differences ranged from -0.80 to 0.20 kg/m2. Long-term outcome predictions showed generally improved health outcomes for the interventions; some appeared cost-effective (e.g., interventions in UK). Ethical concerns around health inequality and the lack of specific legal regulations for personalized nutrition interventions were identified. Choice modeling studies indicated openness to personalized nutrition interventions; decisions were primarily affected by intervention's price.

CONCLUSIONS:

PREVENTOMICS clinical trials have shown promising effectiveness with no major safety concerns, although uncertainties about effectiveness exist due to small samples (n=60-264) and short follow-ups (10-16 weeks). Larger, longer trials are needed for robust evidence before implementation could be considered. Among other considerations, developers should explore financing options and collaborate with policymakers to prevent exclusion of specific groups due to information shortages.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Evaluación de la Tecnología Biomédica / Disparidades en el Estado de Salud Límite: Humans Idioma: En Revista: Int J Technol Assess Health Care Asunto de la revista: PESQUISA EM SERVICOS DE SAUDE Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Evaluación de la Tecnología Biomédica / Disparidades en el Estado de Salud Límite: Humans Idioma: En Revista: Int J Technol Assess Health Care Asunto de la revista: PESQUISA EM SERVICOS DE SAUDE Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido