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Sphingolipid diversity in Candida auris: unraveling interclade and drug resistance fingerprints.
Ali, Basharat; Kumar, Mohit; Kumar, Praveen; Chauhan, Anshu; Usmani, Sana Akhtar; Rudramurthy, Shivaprakash M; Meis, Jacques F; Chakrabarti, Arunaloke; Singh, Ashutosh; Gaur, Naseem A; Mondal, Alok K; Prasad, Rajendra.
Afiliación
  • Ali B; Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology, Amity University Gurgaon, Haryana, 122413, India.
  • Kumar M; School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
  • Kumar P; Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology, Amity University Gurgaon, Haryana, 122413, India.
  • Chauhan A; Yeast Biofuel Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067 India.
  • Usmani SA; Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology, Amity University Gurgaon, Haryana, 122413, India.
  • Rudramurthy SM; Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology, Amity University Gurgaon, Haryana, 122413, India.
  • Meis JF; Department of Biochemistry, University of Lucknow, Lucknow, 226007 India.
  • Chakrabarti A; Postgraduate Institute of Medical Education and Research, Chandigarh,160012 India.
  • Singh A; Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases and Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, 50931 Germany.
  • Gaur NA; Postgraduate Institute of Medical Education and Research, Chandigarh,160012 India.
  • Mondal AK; Department of Biochemistry, University of Lucknow, Lucknow, 226007 India.
  • Prasad R; Yeast Biofuel Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067 India.
FEMS Yeast Res ; 242024 Jan 09.
Article en En | MEDLINE | ID: mdl-38444195
ABSTRACT
In this study, we explored the sphingolipid (SL) landscape in Candida auris, which plays pivotal roles in fungal biology and drug susceptibility. The composition of SLs exhibited substantial variations at both the SL class and molecular species levels among clade isolates. Utilizing principal component analysis, we successfully differentiated the five clades based on their SL class composition. While phytoceramide (PCer) was uniformly the most abundant SL class in all the isolates, other classes showed significant variations. These variations were not limited to SL class level only as the proportion of different molecular species containing variable number of carbons in fatty acid chains also differed between the isolates. Also a comparative analysis revealed abundance of ceramides and glucosylceramides in fluconazole susceptible isolates. Furthermore, by comparing drug-resistant and susceptible isolates within clade IV, we uncovered significant intraclade differences in key SL classes such as high PCer and low long chain base (LCB) content in resistant strains, underscoring the impact of SL heterogeneity on drug resistance development in C. auris. These findings shed light on the multifaceted interplay between genomic diversity, SLs, and drug resistance in this emerging fungal pathogen.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Antifúngicos Idioma: En Revista: FEMS Yeast Res Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Antifúngicos Idioma: En Revista: FEMS Yeast Res Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido