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Lycopene prevents cell death in NRK-52E cells by inhibition of high glucose-activated DNA damage and apoptotic, autophagic, and necrotic pathways.
Usta, Ayse; Yüksek, Veysel; Çetin, Sedat; Dede, Semiha.
Afiliación
  • Usta A; Department of Chemistry, Faculty of Science, Van Yuzuncu Yil University, Van, Turkey.
  • Yüksek V; Department of Medical Laboratory Technician, Ozalp Regional High School, Van Yuzuncu Yil University, Van, Turkey.
  • Çetin S; Department of Veterinary Medicine, Vocational School of Health Services, Ankara Yildirim Beyazit University, Ankara, Turkey.
  • Dede S; Department of Biochemistry, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, Van, Turkey.
J Biochem Mol Toxicol ; 38(3): e23678, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38444079
ABSTRACT
This study aims to investigate the effects of lycopene on apoptotic, autophagic, and necrotic pathways, oxidative status, and DNA damage in diabetic nephropathy at the molecular level. The sample of the study includes seven groups lycopene (L), high glucose (G), high glucose + lycopene (GL), and control (C) groups tested at 12 and 24 h. The expression levels of genes in oxidative, apoptotic, autophagic, and necrotic cell death pathways are determined by reverse transcription-quantitative polymerase chain reaction analysis. The comet assay method is used for the analysis of DNA damage. It is observed that adding lycopene to high glucose for protective purposes reduces the expression of genes related to apoptosis, autophagy, and necrosis, as well as the DNA damage index, compared to cells given high glucose alone. Lycopene can be a safe and effective alternative agent.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Daño del ADN Límite: Humans Idioma: En Revista: J Biochem Mol Toxicol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Daño del ADN Límite: Humans Idioma: En Revista: J Biochem Mol Toxicol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos