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Distinct pathways drive anterior hypoblast specification in the implanting human embryo.
Weatherbee, Bailey A T; Weberling, Antonia; Gantner, Carlos W; Iwamoto-Stohl, Lisa K; Barnikel, Zoe; Barrie, Amy; Campbell, Alison; Cunningham, Paula; Drezet, Cath; Efstathiou, Panagiota; Fishel, Simon; Vindel, Sandra Gutiérrez; Lockwood, Megan; Oakley, Rebecca; Pretty, Catherine; Chowdhury, Nabiha; Richardson, Lucy; Mania, Anastasia; Weavers, Lauren; Christie, Leila; Elder, Kay; Snell, Phillip; Zernicka-Goetz, Magdalena.
Afiliación
  • Weatherbee BAT; Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge, Cambridge, UK.
  • Weberling A; Center for Stem Cell and Organoid Medicine, Perinatal Institute, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Gantner CW; Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge, Cambridge, UK.
  • Iwamoto-Stohl LK; All Souls College, Oxford, UK.
  • Barnikel Z; Nuffield Department of Women's and Reproductive Health, Women's Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK.
  • Barrie A; Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge, Cambridge, UK.
  • Campbell A; Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge, Cambridge, UK.
  • Cunningham P; CARE Fertility, Nottingham, UK.
  • Drezet C; CARE Fertility, Nottingham, UK.
  • Efstathiou P; CARE Fertility, Nottingham, UK.
  • Fishel S; CARE Fertility, Nottingham, UK.
  • Vindel SG; CARE Fertility, Nottingham, UK.
  • Lockwood M; CARE Fertility, Nottingham, UK.
  • Oakley R; CARE Fertility, Nottingham, UK.
  • Pretty C; CARE Fertility, Nottingham, UK.
  • Chowdhury N; CARE Fertility, Nottingham, UK.
  • Richardson L; CARE Fertility, Nottingham, UK.
  • Mania A; CARE Fertility, Nottingham, UK.
  • Weavers L; Herts & Essex Fertility Centre, Bishops College, Cheshunt, UK.
  • Christie L; Herts & Essex Fertility Centre, Bishops College, Cheshunt, UK.
  • Elder K; King's Fertility, Denmark Hill, London, UK.
  • Snell P; King's Fertility, Denmark Hill, London, UK.
  • Zernicka-Goetz M; Bourn Hall Fertility Clinic, Bourn, UK.
Nat Cell Biol ; 26(3): 353-365, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38443567
ABSTRACT
Development requires coordinated interactions between the epiblast, which generates the embryo proper; the trophectoderm, which generates the placenta; and the hypoblast, which forms both the anterior signalling centre and the yolk sac. These interactions remain poorly understood in human embryogenesis because mechanistic studies have only recently become possible. Here we examine signalling interactions post-implantation using human embryos and stem cell models of the epiblast and hypoblast. We find anterior hypoblast specification is NODAL dependent, as in the mouse. However, while BMP inhibits anterior signalling centre specification in the mouse, it is essential for its maintenance in human. We also find contrasting requirements for BMP in the naive pre-implantation epiblast of mouse and human embryos. Finally, we show that NOTCH signalling is important for human epiblast survival. Our findings of conserved and species-specific factors that drive these early stages of embryonic development highlight the strengths of comparative species studies.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embrión de Mamíferos / Estratos Germinativos Límite: Female / Humans / Pregnancy Idioma: En Revista: Nat Cell Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embrión de Mamíferos / Estratos Germinativos Límite: Female / Humans / Pregnancy Idioma: En Revista: Nat Cell Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido