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Missed abortion in the 11-21-week period: Fetal autopsy and placental histopathological analysis of 794 cases.
Emmer, Rony; Ajne, Gunilla; Papadogiannakis, Nikos.
Afiliación
  • Emmer R; Department of Women's Health, Karolinska University Hospital, Stockholm, Sweden.
  • Ajne G; Department of Women's Health, Karolinska University Hospital, Stockholm, Sweden; Div of Obstet and Gyn, Dep of Clinical Science and Intervention, Karolinska Institute, Stockholm, Sweden.
  • Papadogiannakis N; Department of Laboratory Medicine, Division of Pathology, Karolinska Institute, Stockholm, Sweden; Department of Pathology, Karolinska University Hospital, Stockholm, Sweden. Electronic address: nikos.papadogiannakis@ki.se.
Eur J Obstet Gynecol Reprod Biol ; 296: 158-162, 2024 May.
Article en En | MEDLINE | ID: mdl-38442533
ABSTRACT

INTRODUCTION:

Missed abortion (MA) is a type of miscarriage with multiple etiological factors that refers to fetal death with a failure of the retained intrauterine product of conception to be discharged spontaneously. Currently fetal death in missed abortion is categorized according to three main causes Fetal, placental, and maternal factors. The aim of the current study was to contribute and increase knowledge in clinical practice of late first and second trimester MA (Gestational age week 11 + 0 - week 20 + 6). MATERIAL AND

METHODS:

This retrospective case series study includes 794 cases of fetuses and matching placentas sent to the Section of Perinatal Pathology, Department of Pathology, Karolinska Hospital between 2003 and 2019 from five different gynecology departments in the Stockholm region, Sweden.

RESULTS:

The cases were divided into two groups according to gestational length; gestational week 11 + 0-14 + 6 (group A) and 15 + 0-20 + 6 (group B) respectively, and comparisons were made between groups. Fetal growth restriction and placental pathology were more common in late MA, but number of cases with malformation were higher in early MA. Cord pathology was seen in approximately 40 % of the cases and equally distributed in the gestational weeks included.

DISCUSSION:

Fetal growth restriction and placental pathology were more common in late second trimester MA. This might demonstrate an early placental dysfunction affecting fetal growth and may be associated to maternal comorbidity such as autoimmune disease and cardiovascular disease. It is advisable to investigate maternal factors more closely after late second trimester MA before a future pregnancy. The risk for recurrent MA is believed to be low in cases of significant cord pathology.

CONCLUSION:

Cord complications were over-represented in missed abortion suggesting a probable etiopathogenetic link to fetal demise in this condition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aborto Habitual / Aborto Retenido Límite: Female / Humans / Pregnancy Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aborto Habitual / Aborto Retenido Límite: Female / Humans / Pregnancy Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Irlanda