A decade's overview of 2-aminothiophenes and their fused analogs as promising anticancer agents.

Darwish, Donia G; El-Sherief, Hany A M; Abdel-Aziz, Salah A; Abuo-Rahma, Gamal El-Din A

A decade's overview of 2-aminothiophenes and their fused analogs as promising anticancer agents.

Darwish, Donia G; El-Sherief, Hany A M; Abdel-Aziz, Salah A; Abuo-Rahma, Gamal El-Din A.

Afiliación

Darwish DG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Minia, Egypt.
El-Sherief HAM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Minia, Egypt.
Abdel-Aziz SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Minia, Egypt.
Abuo-Rahma GEA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt.

Arch Pharm (Weinheim) ; 357(6): e2300758, 2024 Jun.

Article en En | MEDLINE | ID: mdl-38442316

ABSTRACT

ABSTRACT

Over the past decades, cancer has been a challenging domain for medicinal chemists as it is an international health concern. In association, small molecules such as 2-aminothiophenes and their derivatives showed significant antitumor activity through variable modes of action. Therefore, this article aims to review the advances regarding these core scaffolds over the past 10 years, where 2-aminothiophenes and their fused analogs are classified and discussed according to their biological activity and mode of action, in the interest of boosting new design pathways for medicinal chemists to develop targeted antitumor candidates.

Asunto(s)

Antineoplásicos; Tiofenos; Antineoplásicos/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/química; Humanos; Tiofenos/farmacología; Tiofenos/síntesis química; Tiofenos/química; Relación Estructura-Actividad; Neoplasias/tratamiento farmacológico; Neoplasias/patología; Animales; Estructura Molecular

Palabras clave

2aminothiophene; HDAC inhibitors; antitumor; kinase inhibitors; thieno[2,3d]pyrimidine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiofenos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Alemania

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