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Association between fetal fraction of cell-free DNA and adverse pregnancy outcomes.
Golbasi, Hakan; Bayraktar, Burak; Golbasi, Ceren; Omeroglu, Ibrahim; Adiyaman, Duygu; Alkan, Kaan Okan; Ozdemir, Taha Resid; Ozer, Ozge Kaya; Ozyilmaz, Berk; Ekin, Atalay.
Afiliación
  • Golbasi H; Division of Perinatology, Department of Obstetrics and Gynecology, Bakircay University Cigli Education and Research Hospital, Yeni District., 8780/1 St., Cigli, Izmir, Izmir, Türkiye. drhkngolbasi@gmail.com.
  • Bayraktar B; Division of Perinatology, Department of Obstetrics and Gynecology, University of Health Sciences Tepecik Training and Research Hospital, Izmir, Türkiye. drhkngolbasi@gmail.com.
  • Golbasi C; Division of Perinatology, Department of Obstetrics and Gynecology, University of Health Sciences Ankara Etlik City Hospital, Ankara, Türkiye.
  • Omeroglu I; Department of Obstetrics and Gynecology, University of Health Sciences Tepecik Training and Research Hospital, Izmir, Türkiye.
  • Adiyaman D; Department of Obstetrics and Gynecology, Faculty of Medicine, Izmir Tinaztepe University, Izmir, Türkiye.
  • Alkan KO; Division of Perinatology, Department of Obstetrics and Gynecology, University of Health Sciences Tepecik Training and Research Hospital, Izmir, Türkiye.
  • Ozdemir TR; Division of Perinatology, Department of Obstetrics and Gynecology, University of Health Sciences Tepecik Training and Research Hospital, Izmir, Türkiye.
  • Ozer OK; Department of Obstetrics and Gynecology, Ulm University Hospital, Ulm, Germany.
  • Ozyilmaz B; Department of Obstetrics and Gynecology, University of Health Sciences Tepecik Training and Research Hospital, Izmir, Türkiye.
  • Ekin A; Department of Genetics, University of Health Sciences Tepecik Training and Research Hospital, Izmir, Türkiye.
Arch Gynecol Obstet ; 310(2): 1037-1048, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38441603
ABSTRACT

PURPOSE:

To determine the association between fetal fraction (FF) levels in cell-free fetal DNA (cffDNA) testing and adverse pregnancy outcomes.

METHODS:

This retrospective cohort study, conducted at a single center, involved 2063 pregnant women with normal 1st and 2nd trimester non-invasive prenatal test (NIPT) results between 2016 and 2021. Pregnancy outcomes were examined by determining the < 4% and < 5th percentile (3.6%) cut-off values for low fetal fraction (LFF). Pregnancy outcomes were also examined by dividing the FF into population-based quartiles. Adverse pregnancy outcomes were pregnancy-induced hypertensive diseases (PIHD), gestational diabetes mellitus (GDM), spontaneous preterm birth (PTB), intrahepatic cholestasis of pregnancy (ICP), small for gestational age (SGA), large for gestational age (LGA), low birth weight (LBW), macrosomia, and 1st and 5th minutes low APGAR scores (< 7).

RESULTS:

PIHD was significantly higher in LFF (< 4% and < 5th percentile) cases (p = 0.015 and p < 0.001, respectively). However, in population-based quartiles of FF, PIHD did not differ significantly between groups. Composite adverse maternal outcomes were significantly higher in the FF < 4% group (p = 0.042). When analyzes were adjusted for maternal age, BMI, and gestational age at NIPT, significance was maintained at < 4%, < 5th percentile LFF for PIHD, and < 4% LFF for composite adverse maternal outcomes. However, there was no significant relationship between LFF with GDM, ICP and PTB. Additionally, there was no significant association between low APGAR scores, SGA, LGA, LBW, macrosomia, and LFF concerning neonatal outcomes.

CONCLUSION:

Our study showed that LFF in pregnant women with normal NIPT results may be a predictor of subsequent PIHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resultado del Embarazo / Ácidos Nucleicos Libres de Células Límite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resultado del Embarazo / Ácidos Nucleicos Libres de Células Límite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania