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Age-related differences in macromolecular resonances observed in ultra-short-TE STEAM MR spectra at 7T.
Genovese, Guglielmo; Terpstra, Melissa; Filip, Pavel; Mangia, Silvia; McCarten, J Riley; Hemmy, Laura S; Marjanska, Malgorzata.
Afiliación
  • Genovese G; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
  • Terpstra M; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
  • Filip P; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
  • Mangia S; Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
  • McCarten JR; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
  • Hemmy LS; Geriatric Research, Education and Clinical Center, Veterans Affairs Health Care System, Minneapolis, Minnesota, USA.
  • Marjanska M; Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Magn Reson Med ; 92(1): 4-14, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38441257
ABSTRACT

PURPOSE:

To understand how macromolecular content varies in the human brain with age in a large cohort of healthy subjects.

METHODS:

In-vivo 1H-MR spectra were acquired using ultra-short TE STEAM at 7T in the posterior cingulate cortex. Macromolecular content was studied in 147 datasets from a cohort ranging in age from 19 to 89 y. Three fitting approaches were used to evaluate the macromolecular content (1) a macromolecular resonances model developed for this study; (2) LCModel-simulated macromolecules; and (3) a combination of measured and LCModel-simulated macromolecules. The effect of age on the macromolecular content was investigated by considering age both as a continuous variable (i.e., linear regressions) and as a categorical variable (i.e., multiple comparisons among sub-groups obtained by stratifying data according to age by decade).

RESULTS:

While weak age-related effects were observed for macromolecular peaks at ˜0.9 (MM09), ˜1.2 (MM12), and ˜1.4 (MM14) ppm, moderate to strong effects were observed for peaks at ˜1.7 (MM17), and ˜2.0 (MM20) ppm. Significantly higher MM17 and MM20 content started from 30 to 40 y of age, while for MM09, MM12, and MM14, significantly higher content started from 60 to 70 y of age.

CONCLUSIONS:

Our findings provide insights into age-related differences in macromolecular contents and strengthen the necessity of using age-matched measured macromolecules during quantification.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Sustancias Macromoleculares Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Sustancias Macromoleculares Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos