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Effect of Impaired Awareness of Hypoglycemia on Glucose Decline During and After Exercise in the T1DEXI Study.
Kamimoto, Jorge L Jo; Li, Zoey; Gal, Robin L; Castle, Jessica R; Doyle, Francis J; Jacobs, Peter G; Martin, Corby K; Beck, Roy W; Calhoun, Peter; Riddell, Michael C; Rickels, Michael R.
Afiliación
  • Kamimoto JLJ; Division of Endocrinology, Diabetes & Metabolism, Department of Medicine and Institute for Diabetes, Obesity & Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Li Z; JAEB Center for Health Research, Tampa, FL 33647, USA.
  • Gal RL; JAEB Center for Health Research, Tampa, FL 33647, USA.
  • Castle JR; Harold Schnitzer Diabetes Health Center, Oregon Health & Science University, Portland, OR 97239, USA.
  • Doyle FJ; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02134, USA.
  • Jacobs PG; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.
  • Martin CK; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
  • Beck RW; JAEB Center for Health Research, Tampa, FL 33647, USA.
  • Calhoun P; JAEB Center for Health Research, Tampa, FL 33647, USA.
  • Riddell MC; Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, ON M3J1P3Canada.
  • Rickels MR; Division of Endocrinology, Diabetes & Metabolism, Department of Medicine and Institute for Diabetes, Obesity & Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
J Clin Endocrinol Metab ; 109(9): 2233-2241, 2024 Aug 13.
Article en En | MEDLINE | ID: mdl-38441232
ABSTRACT
CONTEXT Adults with type 1 diabetes (T1D) face the necessity of balancing the benefits of exercise with the potential hazards of hypoglycemia.

OBJECTIVE:

This work aimed to assess whether impaired awareness of hypoglycemia (IAH) affects exercise-associated hypoglycemia in adults with T1D.

METHODS:

We compared continuous glucose monitoring (CGM)-measured glucose during exercise and for 24 hours following exercise from 95 adults with T1D and IAH (Clarke score ≥4 or ≥1 severe hypoglycemic event within the past year) to 95 "aware" adults (Clarke score ≤2 and no severe hypoglycemic event within the past year) matched on sex, age, insulin delivery modality, and glycated hemoglobin A1c. A total of 4236 exercise sessions, and 1794 exercise days and 839 sedentary days, defined as 24 hours following exercise or a day without exercise, respectively, were available for analysis.

RESULTS:

Participants with IAH exhibited a nonsignificant trend toward greater decline in glucose during exercise compared to "aware" (-21 ± 44 vs -19 ± 43 mg/dL [-1.17 ± 2.44 vs -1.05 ± 2.39 mmol/L], adjusted group difference of -4.2 [95% CI, -8.4 to 0.05] mg/dL [-0.23 95% CI, -.47 to 0.003 mmol/L]; P = .051). Individuals with IAH had a higher proportion of days with hypoglycemic events below 70 mg/dL [3.89 mmol/L] (≥15 minutes <70 mg/dL [<3.89 mmol/L]) both on exercise days (51% vs 43%; P = .006) and sedentary days (48% vs 30%; P = .001). The increased odds of experiencing a hypoglycemic event below 70 mg/dL (<3.89 mmol/L) for individuals with IAH compared to "aware" did not differ significantly between exercise and sedentary days (interaction P = .36).

CONCLUSION:

Individuals with IAH have a higher underlying risk of hypoglycemia than "aware" individuals. Exercise does not appear to differentially increase risk for hypoglycemia during the activity, or in the subsequent 24 hours for IAH compared to aware individuals with T1D.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Automonitorización de la Glucosa Sanguínea / Ejercicio Físico / Diabetes Mellitus Tipo 1 / Hipoglucemia Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Automonitorización de la Glucosa Sanguínea / Ejercicio Físico / Diabetes Mellitus Tipo 1 / Hipoglucemia Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos