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Cellular senescence in testicular cancer. Is there a correlation with the preoperative markers and the extent of the tumor? An experimental study.
Tatanis, Vasileios; Veroutis, Dimitris; Pantelis, Pavlos; Theocharous, George; Sarlanis, Helen; Georgiou, Alexandros; Peteinaris, Angelis; Natsos, Anastasios; Moulavasilis, Napoleon; Kavantzas, Nikolaos; Kotsinas, Athanassios; Adamakis, Ioannis.
Afiliación
  • Tatanis V; Department of Urology, University of Patras. tatanisbas@gmail.com.
  • Veroutis D; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), Athens. dimitrisveroutis1@gmail.com.
  • Pantelis P; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), Athens. pavlospantelis7@gmail.com.
  • Theocharous G; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), Athens. theocharousgiorgos@gmail.com.
  • Sarlanis H; Department of Pathology, Medical School, National and Kapodistrian University, Athens. elenisarlani@gmail.com.
  • Georgiou A; Department of Pathology, Medical School, National and Kapodistrian University, Athens. alexandrosge11@gmail.com.
  • Peteinaris A; Department of Urology, University of Patras. peteinarisaggelis@gmail.com.
  • Natsos A; Department of Urology, University of Patras. anatsos@gmail.com.
  • Moulavasilis N; 1st Department of Urology, National and Kapodistrian University of Athens. napomoul@hotmail.com.
  • Kavantzas N; Department of Pathology, Medical School, National and Kapodistrian University, Athens. nkavantz@med.uoa.gr.
  • Kotsinas A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), Athens. akotsin@gmail.com.
  • Adamakis I; 1st Department of Urology, National and Kapodistrian University of Athens. yianton@hotmail.com.
Arch Ital Urol Androl ; 96(1): 12246, 2024 Mar 04.
Article en En | MEDLINE | ID: mdl-38441175
ABSTRACT

PURPOSE:

The aim of this experimental study is to investigate the correlation between the presence of senescent cells and the tumor size, the lymphovascular invasion (LVI), the invasion of rete testis (RTI), the preoperative tumor markers or pathological stage in patients who underwent orchiectomy for malignant purposes.

METHODS:

This experimental study included patients with a history of radical orchiectomy performed from January 2011 to January 2019. The testicular tissue specimens underwent an immunohistopathological process for the detection of the presence of cellular senescence. Besides, the tumor size, the histopathological type, the pathological stage of the tumor and the presence of Lymphovascular (LVI) or rete testis (RTI) invasions were also recorded. Additionally, the preoperative serum levels of alpha-fetoprotein, beta-human chorionic gonadotropin and lactate dehydrogenase were recorded. After the completion of immunohistochemical analysis, the rate of senescent cells in each specimen was also recorded.

RESULTS:

The mean senescent cell rate was estimated to be 14.11±11.32% and 15.46±10.58% in patients with presence of LVI or absence of LVI, respectively (p=0.46). The mean senescent cell rate was calculated at 18.13±12.26% and 12.56±9.38% (p=0.096) in patients with presence of RTI or absence of RTI, respectively. The mean senescent cell rate in the pT1 group was calculated at 14.58 ± 9.82%, while in T2 and T3 groups the mean senescent cell rate was estimated to be 15.22 ± 12.03% and 15.35 ± 14.21%, respectively (p=0.98). A statistically significant correlation was detected between the senescence rate and the tumor size (Pearson score 0.40, p=0.027) and between the rate of senescent cells and the preoperative level of lactate dehydrogenase (LDH) (Pearson score -0.53, p=0.002).

CONCLUSIONS:

The presence of cellular senescence was correlated with the extent of the testicular tumor in terms of tumor size as well as the preoperative level of the LDH serum marker.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Testiculares / Neoplasias de Células Germinales y Embrionarias Límite: Humans / Male Idioma: En Revista: Arch Ital Urol Androl Asunto de la revista: MEDICINA REPRODUTIVA / NEFROLOGIA / UROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Testiculares / Neoplasias de Células Germinales y Embrionarias Límite: Humans / Male Idioma: En Revista: Arch Ital Urol Androl Asunto de la revista: MEDICINA REPRODUTIVA / NEFROLOGIA / UROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Italia