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Seroepidemiology of Toxoplasma gondii Infection in Patients with Liver Disease in Southeastern Iran.
Oveisipour, Atefeh; Hataminejad, Maryam; Fouladi, Bahman; Azizi, Hakim.
Afiliación
  • Oveisipour A; Zabol University of Medical Sciences, Department of Parasitology and Mycology, School of Medicine Zabol University of Medical Sciences, Zabol, Iran.
  • Hataminejad M; Mazandaran University of Medical Sciences, Department of Medical Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
  • Fouladi B; Zabol University of Medical Sciences, Department of Parasitology and Mycology, School of Medicine Zabol University of Medical Sciences, Zabol, Iran.
  • Azizi H; Zabol University of Medical Sciences, Department of Parasitology and Mycology, School of Medicine Zabol University of Medical Sciences, Zabol, Iran.
Recent Adv Antiinfect Drug Discov ; 2024 Mar 04.
Article en En | MEDLINE | ID: mdl-38441016
ABSTRACT

INTRODUCTION:

Recent research has been concentrated on investigating the involvement of Toxoplasma gondii (T. gondii) in the progression of liver disorders. This study aims to investigate the prevalence of T. gondii infection in patients with non-alcoholic fatty liver disease (NAFLD), as well as the effects of toxoplasmosis infection on biological biomarkers such as aspirate transaminase (AST), alanine transaminase (ALT), cholesterol (Chol), and triglyceride (Tg) levels in Sistan, southeast Iran.

METHODS:

A case-control study was conducted between December 2021 and September 2022. The study included 225 patients diagnosed with NAFLD as the case group and 225 healthy blood donors as the control group. The controls were selected from the same region and were matched with the patients based on gender and age. We collected serum samples from all patients and utilized an enzyme-linked immunosorbent assay to analyze them for the existence of anti-T. gondii IgG antibodies. A questionnaire and medical records were utilized to gather data on the patient's demographic factors.

RESULTS:

The prevalence of anti-T. gondii IgG antibodies were 68 (30.2%) in patients with NAFLD, whereas it was 11 (4.88%) in the control group. The seroprevalence of T. gondii in NAFLD patients increased in correlation with age (P < 0.001). The prevalence of NAFLD was significantly greater in the seropositive group compared to the seronegative group (P < 0.001). In addition, the levels of the metabolic markers Chol and Tg were significantly higher in T. gondii seropositive NAFLD patients compared to T. gondii seronegative NAFLD patients.

CONCLUSION:

The findings of this study indicate a high seroprevalence of T. gondii in patients with NAFLD. Further studies are warranted to investigate the underlying mechanisms and potential therapeutic implications of this association.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Recent Adv Antiinfect Drug Discov Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Emiratos Árabes Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Recent Adv Antiinfect Drug Discov Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Emiratos Árabes Unidos