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Siamfuranones A-C, three novel furanone derivatives from the flowers of Uvaria siamensis and their biological activities.
Schevenels, Florian T; Jadsadajerm, Supachai; Lekphrom, Ratsami; Yodsin, Nuttapon; Suebrasri, Thanapat; Senawong, Thanaset; Wisetsai, Awat.
Afiliación
  • Schevenels FT; Department of Chemistry, and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Jadsadajerm S; Department of Industrial Chemistry, Faculty of Applied Science, King Mongkut's University of Technology North Bangkok, Bangkok, Thailand.
  • Lekphrom R; Department of Chemistry, and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Yodsin N; Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand.
  • Suebrasri T; Faculty of Medical Science, Nakhonratchasima College, Nakhonratchasima, Thailand.
  • Senawong T; Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Wisetsai A; Department of Industrial Chemistry, Faculty of Applied Science, King Mongkut's University of Technology North Bangkok, Bangkok, Thailand.
Nat Prod Res ; : 1-10, 2024 Mar 05.
Article en En | MEDLINE | ID: mdl-38440837
ABSTRACT
Three previously undescribed furanone derivatives named siamfuranones A-C (1-3), together with 11 known compounds (4-14), were isolated from the flowers of Uvaria siamensis. Their planar structures were determined through analysis of spectrometric and spectroscopic evidence, while electronic circular dichroism (ECD) calculations were used to determine their absolute configurations. In addition, gauge-including atomic orbitals (GIAO) NMR chemical shift calculation, supported by the advanced statistical method DP4 plus, was used to confirm the relative configuration of siamfuranone B (2). All the isolated compounds were evaluated against two cancer cell lines (A549 and Hela), and screened for antibacterial activities. Furthermore, they were assessed for cytotoxicity against a normal cell line (Vero cell).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido