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Gene Polymorphism Influencing Persistent Bone Resorption in Brown Tumor: A Case Series with Possible Pathogenesis and Potential Therapeutic Approach.
Jain, Ayushi; Sharma, Pooja; N, Sivakumar; Sharma, Kriti; Gupta, Shalini.
Afiliación
  • Jain A; Dept of Oral Pathology, Microbiology and Forensic Odontology, King George's Medical University, Lucknow, 226003 UP India.
  • Sharma P; Dept of Oral Pathology, Microbiology and Forensic Odontology, King George's Medical University, Lucknow, 226003 UP India.
  • N S; Dept of Oral Pathology, Microbiology and Forensic Odontology, All India Institute of Medical Sciences, New Delhi, 110029 India.
  • Sharma K; Dept of Oral Pathology, Microbiology and Forensic Odontology, King George's Medical University, Lucknow, 226003 UP India.
  • Gupta S; Dept of Oral Pathology, Microbiology and Forensic Odontology, King George's Medical University, Lucknow, 226003 UP India.
Indian J Otolaryngol Head Neck Surg ; 76(1): 1178-1182, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38440495
ABSTRACT
Brown tumor represents a terminal stage of bone remodeling process due to an imbalance between osteoclastic and osteoblastic activity. It represents a reparative cellular process, rather than a neoplastic process mostly associated with primary or secondary hyperparathyroidism. Although parathyroidectomy is the first treatment of choice for brown tumors, several cases don't resolve even after normalization of parathyroid hormone levels which leads to surgical intervention. Therefore, to avoid multiple bone surgeries in the same patient, it is crucial to have a conservative approach like targeted therapy which could block certain molecules involved in bone resorption. In this string, we have recognized and quantified three molecules namely sclerostin, MCP-1 and CD73 in brown tumors and correlated their expression with bone resorption pathogenesis and potential therapeutic approach.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Otolaryngol Head Neck Surg Año: 2024 Tipo del documento: Article Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Otolaryngol Head Neck Surg Año: 2024 Tipo del documento: Article Pais de publicación: India