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Exploring the chemical and pharmacological variability of Lepidium meyenii: a comprehensive review of the effects of maca.
Ulloa Del Carpio, Norka; Alvarado-Corella, Diego; Quiñones-Laveriano, Dante M; Araya-Sibaja, Andrea; Vega-Baudrit, José; Monagas-Juan, Maria; Navarro-Hoyos, Mirtha; Villar-López, Martha.
Afiliación
  • Ulloa Del Carpio N; Centro de Investigación Clínica de Medicina Complementaria-CICMEC, Gerencia de Medicina Complementaria, Seguro Social de Salud-EsSalud, Lima, Peru.
  • Alvarado-Corella D; Bioactivity and Sustainable Development (BIODESS) Group, Department of Chemistry, University of Costa Rica (UCR), San Jose, Costa Rica.
  • Quiñones-Laveriano DM; Instituto de Investigaciones de Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Peru.
  • Araya-Sibaja A; Laboratorio Nacional de Nanotecnología, LANOTEC-CeNAT-CONARE, San José, Costa Rica.
  • Vega-Baudrit J; Laboratorio Nacional de Nanotecnología, LANOTEC-CeNAT-CONARE, San José, Costa Rica.
  • Monagas-Juan M; United States Pharmacopeia (USP) Dietary Supplements and Herbal Medicines, Rockville, MD, United States.
  • Navarro-Hoyos M; Bioactivity and Sustainable Development (BIODESS) Group, Department of Chemistry, University of Costa Rica (UCR), San Jose, Costa Rica.
  • Villar-López M; Centro de Investigación Clínica de Medicina Complementaria-CICMEC, Gerencia de Medicina Complementaria, Seguro Social de Salud-EsSalud, Lima, Peru.
Front Pharmacol ; 15: 1360422, 2024.
Article en En | MEDLINE | ID: mdl-38440178
ABSTRACT
Maca (Lepidium meyenii), a biennial herbaceous plant indigenous to the Andes Mountains, has a rich history of traditional use for its purported health benefits. Maca's chemical composition varies due to ecotypes, growth conditions, and post-harvest processing, contributing to its intricate phytochemical profile, including, macamides, macaenes, and glucosinolates, among other components. This review provides an in-depth revision and analysis of Maca's diverse bioactive metabolites, focusing on the pharmacological properties registered in pre-clinical and clinical studies. Maca is generally safe, with rare adverse effects, supported by preclinical studies revealing low toxicity and good human tolerance. Preclinical investigations highlight the benefits attributed to Maca compounds, including neuroprotection, anti-inflammatory properties, immunoregulation, and antioxidant effects. Maca has also shown potential for enhancing fertility, combating fatigue, and exhibiting potential antitumor properties. Maca's versatility extends to metabolic regulation, gastrointestinal health, cardio protection, antihypertensive activity, photoprotection, muscle growth, hepatoprotection, proangiogenic effects, antithrombotic properties, and antiallergic activity. Clinical studies, primarily focused on sexual health, indicate improved sexual desire, erectile function, and subjective wellbeing in men. Maca also shows promise in alleviating menopausal symptoms in women and enhancing physical performance. Further research is essential to uncover the mechanisms and clinical applications of Maca's unique bioactive metabolites, solidifying its place as a subject of growing scientific interest.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: Perú Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: Perú Pais de publicación: Suiza