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Outcomes after lung transplantation from selected donors older than 70 years in a single centre: time to close the debate?
Romero Román, Alejandra; Gil Barturen, Mariana; Crowley Carrasco, Silvana; Hoyos Mejía, Lucas; Naranjo Gómez, Jose Manuel; Córdoba Peláez, Mar; Pérez Redondo, Marina; Royuela Vicente, Ana; García Fadul, Christian; Gómez de Antonio, David; Novoa, Nuria María; Campo-Cañaveral de la Cruz, Jose Luis.
Afiliación
  • Romero Román A; Thoracic Surgery and Lung Transplantation Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Gil Barturen M; Thoracic Surgery and Lung Transplantation Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Crowley Carrasco S; Thoracic Surgery and Lung Transplantation Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Hoyos Mejía L; Thoracic Surgery and Lung Transplantation Department, University Hospital Zurich, Zurich, Switzerland.
  • Naranjo Gómez JM; Thoracic Surgery and Lung Transplantation Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Córdoba Peláez M; Thoracic Surgery and Lung Transplantation Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Pérez Redondo M; Transplant Coordinator, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Royuela Vicente A; Biostatistics Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), CIBERESP, Madrid, Spain.
  • García Fadul C; Pneumology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Gómez de Antonio D; Thoracic Surgery and Lung Transplantation Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Novoa NM; Thoracic Surgery and Lung Transplantation Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Campo-Cañaveral de la Cruz JL; Thoracic Surgery and Lung Transplantation Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
Eur J Cardiothorac Surg ; 65(3)2024 Mar 01.
Article en En | MEDLINE | ID: mdl-38439563
ABSTRACT

OBJECTIVES:

The aim of this study was to compare the outcomes of lung transplantations using grafts from donors aged over 70 years against those performed using younger donors.

METHODS:

This retrospective single-centre analysis includes lung transplants conducted at our institution from January 2014 to June 2022. Lung recipients were classified into 2 groups based on donor age (group A <70 years; group B ≥70 years). Variables regarding demographics, peri and postoperative outcomes and survival were included. The statistical analysis approach included univariable analysis, propensity score matching to address imbalances in donor variables (smoking status), recipient characteristics (sex, age, diagnosis and lung allocation score) and calendar period and survival analysis.

RESULTS:

A total of 353 lung transplants were performed in this period, 47 (13.3%) using grafts from donors aged over 70 years. Donors in group B were more frequently women (70.2% vs 51.6%, P = 0.017), with less smoking history (22% vs 43%, P = 0.002) and longer mechanical ventilation time (3 vs 2 days, P = 0.025). Recipients in group B had a higher lung allocation score (37.5 vs 35, P = 0.035). Postoperative variables were comparable between both groups, except for pulmonary function tests. Group B demonstrated lower forced expiratory volume 1 s levels (2070 vs 2580 ml, P = 0.001). The propensity score matching showed a lower chance of chronic lung allograft dysfunction by 12% for group B. One-, three- and five-year survival was equal between the groups.

CONCLUSIONS:

The use of selected expanded-criteria donors aged over 70 years did not result in increased postoperative morbidity, early mortality or survival in this study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Tejidos / Trasplante de Pulmón Límite: Aged / Aged80 / Female / Humans Idioma: En Revista: Eur J Cardiothorac Surg Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Tejidos / Trasplante de Pulmón Límite: Aged / Aged80 / Female / Humans Idioma: En Revista: Eur J Cardiothorac Surg Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania