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Associations of maternal serum concentration of iron-related indicators with birth outcomes in Chinese: a pilot prospective cohort study.
Chen, Geng-Dong; Li, Peng-Sheng; Zhou, Zi-Xing; Wang, Hai-Yan; Gou, Xiao-Yan; Ye, Shao-Xin; Lin, Dong-Xin; Fan, Da-Zhi; Wang, Li-Juan; Liu, Zheng-Ping.
Afiliación
  • Chen GD; Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, 528000, Foshan city, Guangdong Province, China. chgengd@163.com.
  • Li PS; Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, 528000, Foshan city, Guangdong Province, China.
  • Zhou ZX; Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, 528000, Foshan city, Guangdong Province, China.
  • Wang HY; Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, 528000, Foshan city, Guangdong Province, China.
  • Gou XY; Biobank of Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, 528000, Foshan, Guangdong, China.
  • Ye SX; Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, 528000, Foshan city, Guangdong Province, China.
  • Lin DX; Biobank of Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, 528000, Foshan, Guangdong, China.
  • Fan DZ; Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, 528000, Foshan city, Guangdong Province, China.
  • Wang LJ; Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, 528000, Foshan city, Guangdong Province, China.
  • Liu ZP; Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, 528000, Foshan city, Guangdong Province, China.
Ital J Pediatr ; 50(1): 39, 2024 Mar 05.
Article en En | MEDLINE | ID: mdl-38439018
ABSTRACT

BACKGROUND:

Previous studies of maternal iron and birth outcomes have been limited to single indicators that do not reflect the comprehensive relationship with birth outcomes. We aimed to investigate the relationship between maternal iron metabolism and neonatal anthropometric indicators using comprehensive iron-related indicators.

METHODS:

A total of 914 Chinese mother-child dyads were enrolled in this prospective study. Subjects' blood samples were collected at ≤ 14 weeks of gestation. Serum concentrations of iron-related indicators were measured by enzyme-linked immunosorbent assay (ELISA). Femur length was measured by B-ultrasound nearest delivery. Neonatal anthropometric indicators were collected from medical records.

RESULTS:

After adjustment for potential covariates, higher iron (per one standard deviation, SD increase) was detrimentally associated with - 0.22 mm lower femur length, whereas higher transferrin (per one SD increase) was associated with 0.20 mm higher femur length. Compared with normal subjects (10th-90th percentiles), subjects with extremely high (> 90th percentile) iron concentration were detrimentally associated with lower femur length, birth weight, and chest circumference, and a higher risk of low birth weight, LBW (HR 3.92, 95%CI 1.28, 12.0). Subjects with high concentration of soluble transferrin receptor, sTFR and transferrin (> 90th percentile) were associated with higher femur length. Subjects with low concentration of iron and ferritin concentrations (< 10th percentile) were associated with a higher risk of LBW (HR 4.10, 95%CI 1.17, 14.3) and macrosomia (HR 2.79, 95%CI 1.06, 7.35), respectively.

CONCLUSIONS:

Maternal iron overload in early pregnancy may be detrimentally associated with neonatal anthropometric indicators and adverse birth outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pueblo Asiatico / Hierro Límite: Female / Humans / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Ital J Pediatr Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pueblo Asiatico / Hierro Límite: Female / Humans / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Ital J Pediatr Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido