Your browser doesn't support javascript.
loading
Pharmacological preclinical comparison of tenecteplase and alteplase for the treatment of acute stroke.
Correa-Paz, Clara; Pérez-Mato, María; Bellemain-Sagnard, Mathys; González-Domínguez, Marco; Marie, Pauline; Pérez-Gayol, Lara; López-Arias, Esteban; Del Pozo-Filíu, Lucia; López-Amoedo, Sonia; Bugallo-Casal, Ana; Alonso-Alonso, María Luz; Candamo-Lourido, María; Santamaría-Cadavid, María; Arias-Rivas, Susana; Rodríguez-Yañez, Manuel; Iglesias-Rey, Ramón; Castillo, José; Vivien, Denis; Rubio, Marina; Campos, Francisco.
Afiliación
  • Correa-Paz C; Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • Pérez-Mato M; Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Universidad Autónoma de Madrid, Madrid, Spain.
  • Bellemain-Sagnard M; Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), GIP Cyceron, Institute Blood and Brain @ Caen-Normandie (BB@C), Caen, France.
  • González-Domínguez M; Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • Marie P; Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), GIP Cyceron, Institute Blood and Brain @ Caen-Normandie (BB@C), Caen, France.
  • Pérez-Gayol L; Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • López-Arias E; Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • Del Pozo-Filíu L; Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • López-Amoedo S; Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • Bugallo-Casal A; Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • Alonso-Alonso ML; Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), GIP Cyceron, Institute Blood and Brain @ Caen-Normandie (BB@C), Caen, France.
  • Candamo-Lourido M; Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), GIP Cyceron, Institute Blood and Brain @ Caen-Normandie (BB@C), Caen, France.
  • Santamaría-Cadavid M; Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • Arias-Rivas S; Stroke Unit, Department of Neurology, Hospital Clínico Universitario, A Coruña, Spain.
  • Rodríguez-Yañez M; Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • Iglesias-Rey R; Stroke Unit, Department of Neurology, Hospital Clínico Universitario, A Coruña, Spain.
  • Castillo J; Translational Stroke Laboratory (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • Vivien D; Stroke Unit, Department of Neurology, Hospital Clínico Universitario, A Coruña, Spain.
  • Rubio M; Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
  • Campos F; Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), A Coruña, Spain.
J Cereb Blood Flow Metab ; 44(8): 1306-1318, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38436292
ABSTRACT
Alteplase (rtPA) remains the standard thrombolytic drug for acute ischemic stroke. However, new rtPA-derived molecules, such as tenecteplase (TNK), with prolonged half-lives following a single bolus administration, have been developed. Although TNK is currently under clinical evaluation, the limited preclinical data highlight the need for additional studies to elucidate its benefits. The toxicities of rtPA and TNK were evaluated in endothelial cells, astrocytes, and neuronal cells. In addition, their in vivo efficacy was independently assessed at two research centers using an ischemic thromboembolic mouse model. Both therapies were tested via early (20 and 30 min) and late administration (4 and 4.5 h) after stroke. rtPA, but not TNK, caused cell death only in neuronal cultures. Mice were less sensitive to thrombolytic therapies than humans, requiring doses 10-fold higher than the established clinical dose. A single bolus dose of 2.5 mg/kg TNK led to an infarct reduction similar to perfusion with 10 mg/kg of rtPA. Early administration of TNK decreased the hemorrhagic transformations compared to that by the early administration of rtPA; however, this result was not obtained following late administration. These two independent preclinical studies support the use of TNK as a promising reperfusion alternative to rtPA.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activador de Tejido Plasminógeno / Fibrinolíticos / Tenecteplasa Límite: Animals / Humans / Male Idioma: En Revista: J Cereb Blood Flow Metab Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activador de Tejido Plasminógeno / Fibrinolíticos / Tenecteplasa Límite: Animals / Humans / Male Idioma: En Revista: J Cereb Blood Flow Metab Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos