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Injectable and Conductive Nanomicelle Hydrogel with α-Tocopherol Encapsulation for Enhanced Myocardial Infarction Repair.
Zhang, Feng; Zhang, Yike; Qian, Sichong; Qian, Xuetian; Jiao, Jincheng; Ma, Biao; Chen, Jiuzhou; Cheng, Hongyi; Li, Xiaopei; Lin, Yongping; Li, Haiyang; Cui, Chang; Chen, Minglong.
Afiliación
  • Zhang F; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
  • Zhang Y; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
  • Qian S; Department of Cardiac Surgery, Beijing Anzhen Hospital, Beijing 100029, China.
  • Qian X; Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
  • Jiao J; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
  • Ma B; State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
  • Chen J; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
  • Cheng H; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
  • Li X; Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
  • Lin Y; Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou 225300, China.
  • Li H; Department of Cardiac Surgery, Beijing Anzhen Hospital, Beijing 100029, China.
  • Cui C; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
  • Chen M; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
ACS Nano ; 18(14): 10216-10229, 2024 Apr 09.
Article en En | MEDLINE | ID: mdl-38436241
ABSTRACT
Substantial advancements have been achieved in the realm of cardiac tissue repair utilizing functional hydrogel materials. Additionally, drug-loaded hydrogels have emerged as a research hotspot for modulating adverse microenvironments and preventing left ventricular remodeling after myocardial infarction (MI), thereby fostering improved reparative outcomes. In this study, diacrylated Pluronic F127 micelles were used as macro-cross-linkers for the hydrogel, and the hydrophobic drug α-tocopherol (α-TOH) was loaded. Through the in situ synthesis of polydopamine (PDA) and the incorporation of conductive components, an injectable and highly compliant antioxidant/conductive composite FPDA hydrogel was constructed. The hydrogel exhibited exceptional stretchability, high toughness, good conductivity, cell affinity, and tissue adhesion. In a rabbit model, the material was surgically implanted onto the myocardial tissue, subsequent to the ligation of the left anterior descending coronary artery. Four weeks postimplantation, there was discernible functional recovery, manifesting as augmented fractional shortening and ejection fraction, alongside reduced infarcted areas. The findings of this investigation underscore the substantial utility of FPDA hydrogels given their proactive capacity to modulate the post-MI infarct microenvironment and thereby enhance the therapeutic outcomes of myocardial infarction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Infarto del Miocardio Límite: Animals Idioma: En Revista: ACS Nano Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Infarto del Miocardio Límite: Animals Idioma: En Revista: ACS Nano Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos