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Proportions and characteristics of interval cancer in annual fecal immunochemical test screening and postcolonoscopy colorectal cancer: Results from a Japanese multicenter prospective study using questionnaires, the C-DETECT study.
Sekiguchi, Masau; Kishida, Yoshihiro; Ikematsu, Hiroaki; Konno, Maki; Mizuguchi, Yasuhiko; Hotta, Kinichi; Imai, Kenichiro; Ito, Sayo; Takada, Kazunori; Shiomi, Akio; Yasui, Hirofumi; Tsukamoto, Shunsuke; Hirano, Hidekazu; Kobayashi, Nozomu; Saito, Yutaka; Inaba, Atsushi; Shinmura, Kensuke; Konishi, Jun; Ozawa, Heita; Fujita, Shin; Murakami, Yoshitaka; Matsuda, Takahisa.
Afiliación
  • Sekiguchi M; Cancer Screening Center, National Cancer Center Hospital, Tokyo, Japan.
  • Kishida Y; Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
  • Ikematsu H; Division of Screening Technology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
  • Konno M; Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
  • Mizuguchi Y; Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan.
  • Hotta K; Department of Gastroenterology, Tochigi Cancer Center, Tochigi, Japan.
  • Imai K; Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
  • Ito S; Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
  • Takada K; Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
  • Shiomi A; Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
  • Yasui H; Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
  • Tsukamoto S; Division of Colorectal Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
  • Hirano H; Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
  • Kobayashi N; Department of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Saito Y; Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
  • Inaba A; Cancer Screening Center, National Cancer Center Hospital, Tokyo, Japan.
  • Shinmura K; Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
  • Konishi J; Division of Screening Technology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
  • Ozawa H; Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
  • Fujita S; Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan.
  • Murakami Y; Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan.
  • Matsuda T; Department of Gastroenterology, Tochigi Cancer Center, Tochigi, Japan.
Dig Endosc ; 2024 Mar 03.
Article en En | MEDLINE | ID: mdl-38433322
ABSTRACT

OBJECTIVES:

There are several types of colorectal cancer (CRC) according to the detection methods and intervals, including interval CRC (iCRC) and postcolonoscopy CRC (PCCRC). We aimed to examine their proportions and characteristics.

METHODS:

We conducted a multicenter prospective study using questionnaires in Japan ("C-DETECT study"), in which differences in CRC characteristics according to detection methods and intervals were examined from consecutive adult patients. Because the annual fecal immunochemical test (FIT) was used in population-based screening, the annual FIT-iCRC was assessed.

RESULTS:

In total, 1241 CRC patients (1064 with invasive CRC) were included. Annual FIT-iCRC (a), 3-year PCCRC (b), and CRC detected within 1 year after a positive FIT with noncompliance to colonoscopy (c) accounted for 4.5%, 7.0%, and 3.9% of all CRCs, respectively, and for 3.9%, 5.4%, and 4.3% of invasive CRCs, respectively. The comparison among these (a, b, c) and other CRCs (d) demonstrated differences in the proportions of ≥T2 invasion ([a] 58.9%, [b] 44.8%, [c] 87.5%, [d] 73.0%), metastasis ([a] 33.9%, [b] 21.8%, [c] 54.2%, [d] 43.9%), right-sided CRC ([a] 42.9%, [b] 40.2%, [c] 18.8%, [d] 28.6%), and female sex ([a] 53.6%, [b] 49.4%, [c] 27.1%, [d] 41.6%). In metastatic CRC, (a) and (b) showed a higher proportions of BRAF mutations ([a] [b] 12.0%, [c] [d] 3.1%).

CONCLUSIONS:

Annual FIT-iCRC and 3-year PCCRC existed in nonnegligible proportions. They were characterized by higher proportions of right-sided tumors, female sex, and BRAF mutations. These findings suggest that annual FIT-iCRC and 3-year PCCRC may have biological features different from those of other CRCs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dig Endosc Asunto de la revista: DIAGNOSTICO POR IMAGEM / GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dig Endosc Asunto de la revista: DIAGNOSTICO POR IMAGEM / GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia