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Persons chronically exposed to low doses of ionizing radiation: A cytogenetic dosimetry study.
Cherednichenko, Oksana; Pilyugina, Anastassiya; Nuraliev, Serikbai; Azizbekova, Dinara.
Afiliación
  • Cherednichenko O; Laboratory of Genetic Monitoring, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan. Electronic address: cherogen70@mail.ru.
  • Pilyugina A; Laboratory of Genetic Monitoring, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan.
  • Nuraliev S; Laboratory of Genetic Monitoring, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan.
  • Azizbekova D; Laboratory of Genetic Monitoring, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan.
Mutat Res Genet Toxicol Environ Mutagen ; 894: 503728, 2024.
Article en En | MEDLINE | ID: mdl-38432778
ABSTRACT
The dosimetry and control of exposure for individuals chronically exposed to ionizing radiation are important and complex issues. Assessment may be optimized by evaluating individual adaptation and radiosensitivity, but it is not possible for a single model to account for all relevant parameters. Our goal was to develop approaches for the calculation of doses for persons chronically exposed to ionizing radiation, taking their radiosensitivities into consideration. On the basis of ex vivo radiation of blood samples, dose-effect models were constructed for dose ranges 0.01-2.0 and 0.01-0.4 Gy, using different cytogenetic criteria. The frequencies of "dicentric chromosomes and rings" at low doses are too low to have predictive value. The different responses of subjects to radiation made it possible to categorize them according to their radiosensitivities and to generate separate dose-effect curves for radiosensitive, average, and radioresistant individuals, reducing the amount of error in retrospective dosimetry.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiación Ionizante / Tolerancia a Radiación Límite: Humans Idioma: En Revista: Mutat Res Genet Toxicol Environ Mutagen Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiación Ionizante / Tolerancia a Radiación Límite: Humans Idioma: En Revista: Mutat Res Genet Toxicol Environ Mutagen Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos