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The effects of prenatal and postnatal high-dose vitamin B-12 supplementation on human milk vitamin B-12: a randomized, double-blind, placebo-controlled trial in Tanzania.
Wang, Dongqing; Shahab-Ferdows, Setareh; Lweno, Omar N; Hampel, Daniela; Method, Balama; Yelverton, Cara A; Nguyen, Christine H; Aboud, Said; Allen, Lindsay H; Fawzi, Wafaie W.
Afiliación
  • Wang D; Department of Global and Community Health, College of Public Health, George Mason University, Fairfax, VA, United States. Electronic address: dwang25@gmu.edu.
  • Shahab-Ferdows S; Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, United States.
  • Lweno ON; Ifakara Health Institute, Bagamoyo Research and Training Center, Bagamoyo, Tanzania.
  • Hampel D; Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, United States; Department of Nutrition, University of California, Davis, CA, United States.
  • Method B; Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  • Yelverton CA; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States.
  • Nguyen CH; Department of Global and Community Health, College of Public Health, George Mason University, Fairfax, VA, United States.
  • Aboud S; Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  • Allen LH; Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, United States.
  • Fawzi WW; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan Schoo
Am J Clin Nutr ; 119(3): 730-739, 2024 03.
Article en En | MEDLINE | ID: mdl-38432714
ABSTRACT

BACKGROUND:

Vitamin B-12 status in human milk (HM) has critical implications for infant growth and development. Few studies have separately evaluated the effects of prenatal and postnatal maternal high-dose vitamin B-12 supplementation on HM vitamin B-12 concentration.

OBJECTIVES:

This randomized controlled trial aimed to assess the effects of prenatal and postnatal vitamin B-12 supplementation on HM vitamin B-12 at 6 wk and 7 mo postpartum.

METHODS:

Pregnant women were enrolled in Dar es Salaam, Tanzania, between 2001 and 2004. From recruitment (12-27 weeks of gestation) through 6 wk postpartum, participants were randomly assigned to daily oral multiple micronutrient supplementation or placebo. From 6 wk to 18 mo postpartum, a subset of participants was randomly assigned to a postnatal supplement or placebo. The supplement included 50 µg/d of vitamin B-12 and various other vitamins. HM vitamin B-12 concentrations were analyzed at 6 wk and 7 mo postpartum for 412 participants.

RESULTS:

The prevalence of HM vitamin B-12 of <310 pmol/L was 73.3% and 68.4% at 6 wk and 7 mo postpartum, respectively. Prenatal supplementation increased HM vitamin B-12 concentration (percent difference 34.4; 95% CI 17.0, 54.5; P < 0.001) at 6 wk; this effect was not present at 7 mo. Postnatal supplementation increased HM vitamin B-12 concentration (percent difference 15.9; 95% CI 1.91, 31.9; P = 0.025) at 7 mo. Effect modification between prenatal and postnatal supplementation on HM vitamin B-12 status at 7 mo was found, with the effects of prenatal and postnatal supplements more pronounced among those receiving control during the other period; the prenatal supplement had a greater effect with postnatal control, and the postnatal supplement had a greater effect with prenatal control.

CONCLUSIONS:

Prenatal maternal vitamin B-12 supplementation has benefits on short-term HM status, and postnatal maternal vitamin B-12 supplementation has benefits on long-term HM status. This trial was registered at clinicaltrials.gov as NCT00197548. https//clinicaltrials.gov/ct2/show/NCT00197548.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina B 12 / Leche Humana Límite: Female / Humans / Infant / Pregnancy País/Región como asunto: Africa Idioma: En Revista: Am J Clin Nutr Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina B 12 / Leche Humana Límite: Female / Humans / Infant / Pregnancy País/Región como asunto: Africa Idioma: En Revista: Am J Clin Nutr Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos