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A Mendelian Randomisation Analysis Reveals No Relationship Between Periodontitis and Coronary Atherosclerosis.
Li, Zhengrui; Wang, Qi; Huang, Xufeng; Wu, Yinteng; Fu, Rao; Wen, Xutao; Liu, Ji'An; Chen, Yuanguo; Liu, Ying; Zhang, Ling.
Afiliación
  • Li Z; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinica
  • Wang Q; Jiangsu University, Zhenjiang, China.
  • Huang X; Faculty of Dentistry, University of Debrecen, Debrecen, Hungary.
  • Wu Y; Department of Orthopedic and Trauma Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, China.
  • Fu R; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinica
  • Wen X; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinica
  • Liu J; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinica
  • Chen Y; Ya'an People's Hospital, Department of Cardiovascular Medicine Ya'an, Sichuan, China.
  • Liu Y; Department of Cardiology, Sixth Medical Center, PLA General Hospital, Beijing, China. Electronic address: liuying@medmail.com.cn.
  • Zhang L; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinica
Int Dent J ; 74(4): 705-712, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38431470
ABSTRACT

OBJECTIVES:

Growing evidence appears to intimate a profound connection between periodontitis and coronary atherosclerosis (CA), yet the existence of a causal relationship remains unclear. Through the implementation of Mendelian randomization analysis, we further evaluated the potential causal link between chronic/acute periodontitis (CP/AP) and CA.

METHODS:

Utilizing genome-wide association study (GWAS) summary statistics, we incorporated periodontitis data derived from European samples (n1 = 198,441; n2 = 195,762) and CA data from 61,194 cases. We conducted a 2 sample, bidirectional Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW) method as the main analytical approach. Supplementary analyses were executed through MR Egger, Weighted median (WM), IVW, Simple mode, and Weighted mode approaches.

RESULTS:

The IVW analysis revealed no significant causal relationship between CA and periodontitis (CA-CP OR = 2.110, 95% CI = 0.208-21.317, P = .527; CA-AP OR = 0.414, 95% CI = 0.051-3.384, P = .644). Similarly, the bidirectional analysis did not identify impact of periodontitis on CA (OR = 1.000, 95% CI = 0.999-1.001, P = .953). The supplementary analyses corroborated these findings.

CONCLUSIONS:

While studies highlighting a correlation between periodontitis and CA, our comprehensive analysis does not corroborate a causal association between periodontitis and CA. Further research is needed to elucidate other potential shared mechanisms and causal evidence between periodontitis and CA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Enfermedad de la Arteria Coronaria / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana Límite: Humans Idioma: En Revista: Int Dent J Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Enfermedad de la Arteria Coronaria / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana Límite: Humans Idioma: En Revista: Int Dent J Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido