Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients.
J Sport Health Sci
; 13(4): 548-558, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38431193
ABSTRACT
BACKGROUND:
Hemodialysis (HD) per se is a risk factor for thrombosis. Considering the growing body of evidence on blood-flow restriction (BFR) exercise in HD patients, identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training model. The aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise (RE) with BFR on this molecule.METHODS:
Two hundred and six HD patients volunteered for this study (all with a glomerular filtration rate of <15 mL/min/1.73 m2). The REâ¯+â¯BFR session consisted of 50% arterial occlusion pressure during 50 min sessions of HD (intradialytic exercise). RE repetitions included concentric and eccentric lifting phases (each lasting 2 s) and were supervised by a strength and conditioning specialist.RESULTS:
Several variables were associated with elevated levels of D-dimer, including higher blood glucose, citrate use, recent cardiovascular events, recent intercurrents, higher inflammatory status, catheter as vascular access, older patients (>70 years old), and HD vintage. Furthermore, REâ¯+â¯BFR significantly increases D-dimer after 4 h. Patients with borderline baseline D-dimer levels (400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range (≥500 ng/mL).CONCLUSION:
These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo REâ¯+â¯BFR. D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during REâ¯+â¯BFR.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trombosis
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Productos de Degradación de Fibrina-Fibrinógeno
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Diálisis Renal
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Entrenamiento de Fuerza
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Sport Health Sci
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
China