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Acute malaria suppresses the B lymphocytic niche in the bone marrow through the alteration of CXCL12-abundant reticular cells.
Lee, Michelle Sue Jann; Matsuo-Dapaah, Julia; Del Rosario Zorrilla, Camila; Omatsu, Yoshiki; Nagasawa, Takashi; Uemura, Shun; Iwama, Atsushi; Ishii, Ken J; Coban, Cevayir.
Afiliación
  • Lee MSJ; Division of Malaria Immunology, Department of Microbiology and Immunology, The Institute of Medical Science (IMSUT), The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Matsuo-Dapaah J; International Vaccine Design Center, The Institute of Medical Science (IMSUT), The University of Tokyo, Tokyo 108-8639, Japan.
  • Del Rosario Zorrilla C; Division of Malaria Immunology, Department of Microbiology and Immunology, The Institute of Medical Science (IMSUT), The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Omatsu Y; Division of Malaria Immunology, Department of Microbiology and Immunology, The Institute of Medical Science (IMSUT), The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Nagasawa T; Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
  • Uemura S; Laboratory of Stem Cell Biology and Developmental Immunology, WPI Immunology Frontier Research Center (IFReC), Osaka University, Osaka 565-0871, Japan.
  • Iwama A; Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
  • Ishii KJ; Laboratory of Stem Cell Biology and Developmental Immunology, WPI Immunology Frontier Research Center (IFReC), Osaka University, Osaka 565-0871, Japan.
  • Coban C; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science (IMSUT), The University of Tokyo, Tokyo 108-8639, Japan.
Int Immunol ; 36(7): 339-352, 2024 Jun 08.
Article en En | MEDLINE | ID: mdl-38430523
ABSTRACT
Bone marrow is a dynamic organ composed of stem cells that constantly receive signals from stromal cells and other hematopoietic cells in the niches of the bone marrow to maintain hematopoiesis and generate immune cells. Perturbation of the bone marrow microenvironment by infection and inflammation affects hematopoiesis and may affect immune cell development. Little is known about the effect of malaria on the bone marrow stromal cells that govern the hematopoietic stem cell (HSC) niche. In this study, we demonstrate that the mesenchymal stromal CXCL12-abundant reticular (CAR) cell population is reduced during acute malaria infection. The reduction of CXCL12 and interleukin-7 signals in the bone marrow impairs the lymphopoietic niche, leading to the depletion of common lymphoid progenitors, B cell progenitors, and mature B cells, including plasma cells in the bone marrow. We found that interferon-γ (IFNγ) is responsible for the upregulation of Sca1 on CAR cells, yet the decline in CAR cell and B cell populations in the bone marrow is IFNγ-independent. In contrast to the decline in B cell populations, HSCs and multipotent progenitors increased with the expansion of myelopoiesis and erythropoiesis, indicating a bias in the differentiation of multipotent progenitors during malaria infection. These findings suggest that malaria may affect host immunity by modulating the bone marrow niche.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Linfocitos B / Quimiocina CXCL12 / Malaria / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Int Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Linfocitos B / Quimiocina CXCL12 / Malaria / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Int Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido